A complex game of hide and seek: the search for new antifungals.
A complex game of hide and seek: the search for new antifungals.
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DOI：
10.1039/c6md00222f
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发表时间：
2016-07-01
期刊：
影响因子：
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通讯作者：
Green KD
中科院分区：
文献类型：
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作者：
Ngo HX;Garneau-Tsodikova S;Green KD
真菌感染每年直接影响数百万人。除了人类的侵入性真菌感染之外，构成我们主要食物来源的植物和动物也容易受到这些真核微生物引起的疾病。对抗真菌药物的需求不仅满足我们的医疗需求，而且还用于农业和畜牧业，导致对新型抗真菌药物的高需求。在此，我们概述了医学和农业中最常用的抗真菌药物。我们还总结了针对医学/农业相关真菌菌株的新药剂的发现/开发的最新进展（从 2010 年至 2016 年），以及与其生物活性、作用模式和耐药机制相关的信息。
Fungal infections directly affect millions of people each year. In addition to the invasive fungal infections of humans, the plants and animals that comprise our primary food source are also susceptible to diseases caused by these eukaryotic microbes. The need for antifungals, not only for our medical needs, but also for use in agriculture and livestock causes a high demand for novel antimycotics. Herein, we provide an overview of the most commonly used antifungals in medicine and agriculture. We also present a summary of the recent progress (from 2010–2016) in the discovery/development of new agents against fungal strains of medical/agricultural relevance, as well as information related to their biological activity, their mode(s) of action, and their mechanism(s) of resistance.