Solid-phase synthesis and modification of thiazole orange and its derivatives and their spectral properties
Solid-phase synthesis and modification of thiazole orange and its derivatives and their spectral properties
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DOI：
10.1021/cc070045x
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发表时间：
2007-11-01
影响因子：
--
通讯作者：
Gu, Yingchun
中科院分区：
文献类型：
--
作者：
Fei, Xuening;Yang, Shaobin;Gu, Yingchun
A new solid-phase synthesis is shown to be effective in the preparation of cyanine dye Thiazole Orange (TO) and its derivatives, which can be obtained as a traceless cleavage of the Merrifield resin method. The influence of different solvents, substitutional groups, introduced to benzothiazole such as chlorine, methyl, and nitro was extensively studied. The changes of the special characteristic and fluorescence intensity of the TO derivatives were described. The phenomenon of the synergetic effect was also depicted after modifying the TO molecule with chitosan oligosaccharide (CTS) at the end of the alkyl, which can effectively improve the sensitivity of the fluorescent probe.
