Midlife decline in declarative memory consolidation is correlated with a decline in slow wave sleep
Midlife decline in declarative memory consolidation is correlated with a decline in slow wave sleep
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DOI：
10.1101/lm.470507
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发表时间：
2007-05-01
影响因子：
2
通讯作者：
Junghanns, Klaus
中科院分区：
文献类型：
--
作者：
Backhaus, Jutta;Born, Jan;Junghanns, Klaus
睡眠结构和记忆功能都强烈依赖于年龄。尤其是慢波睡眠（SWS），随着年龄的增长而急剧减少，从30岁以后就开始了。SWS通常在夜间早期睡眠中占主导地位，并与陈述性记忆巩固有关。然而，在整个生命周期中，睡眠变化对睡眠相关记忆巩固的影响迄今尚未得到评估。在这里，我们比较了年轻和中年健康人在睡眠中的陈述性记忆巩固（单词对关联）。年龄组（18 - 25岁vs. 48 - 55岁）在分别包括夜间睡眠的前半段和后半段的记忆期之前的学习表现没有差异。然而，在早期保留睡眠后，年轻受试者明显比中年人表现出更多的SWS (62.3 +/- 3.7 min vs. 18.4 +/- 7.2 min, P < 0.001)，中年人对单词对的检索明显比年轻人差（P < 0.001）。相比之下，晚睡后的陈述性记忆保留在两组之间没有差异，晚睡后的陈述性记忆保留通常比早睡后的要差（P = 0.005）。当两个年龄组的睡眠时间包含相同数量的SWS时，即，在年轻人的晚睡和中年人的早睡中，陈述性记忆的保留是相同的。我们的研究结果表明，与睡眠相关的陈述性记忆巩固在中年时期就已经出现，并且与早期夜间SWS的减少有关。
Sleep architecture as well as memory function are strongly age dependent. Slow wave sleep ( SWS), in particular, decreases dramatically with increasing age, starting already beyond the age of 30. SWS normally predominates during early nocturnal sleep and is implicated in declarative memory consolidation. However, the consequences of changes in sleep across the life span for sleep- associated memory consolidation have not been evaluated so far. Here, we compared declarative memory consolidation ( for word- pair associates) during sleep in young and middle- aged healthy humans. The age groups ( 18 - 25 vs. 48 - 55 yr) did not differ with regard to learning performance before retention periods that covered, respectively, the first and second half of nocturnal sleep. However, after early retention sleep, where the younger subjects showed distinctly more SWS than the middle- aged (62.3 +/- 3.7 min vs. 18.4 +/- 7.2 min, P < 0.001), retrieval of the word pairs in the middle- aged was clearly worse than in the young (P < 0.001). In contrast, declarative memory retention did not differ between groups after late sleep, where retention was generally worse than after early sleep ( P = 0.005). Retention of declarative memories was the same in both age groups when sleep periods containing equal amounts of SWS were compared, i. e., across late sleep in the young and across early sleep in the middle- aged. Our results indicate a decline in sleep- associated declarative memory consolidation that develops already during midlife and is associated with a decrease in early nocturnal SWS.