Compensated deleterious mutations in insect genomes
Compensated deleterious mutations in insect genomes
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DOI：
10.1126/science.1100522
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发表时间：
2004-11-26
期刊：
影响因子：
56.9
通讯作者：
Hartl, DL
中科院分区：
文献类型：
--
作者：
Kulathinal, RJ;Bettencourt, BR;Hartl, DL
人们对氨基酸相互作用在蛋白质和表型进化中的重要性知之甚少。在这里，我们研究在果蝇中致病的突变是否通过在其他双翅目基因组中的上位作用而固定。致病氨基酸位点的总体差异减少。然而，在这些位点上，大约10%的替换携带与黑腹果蝇突变体中发现的完全相同的致病氨基酸。因此，补偿性突变(S)一定是进化出来的。令人惊讶的是，10%的比例不受系统发育距离的影响。这些结果支持一种选择驱动的过程，该过程允许补偿的氨基酸替换在具有大量种群的分类群中迅速固定。
Relatively little is known about the importance of amino acid interactions in protein and phenotypic evolution. Here we examine whether mutations that are pathogenic in Drosophila melanogaster become fixed via epistasis in other Dipteran genomes. Overall divergence at pathogenic amino acid sites is reduced. However, similar to10% of the substitutions at these sites carry the exact same pathogenic amino acid found in D. melanogaster mutants. Hence compensatory mutation(s) must have evolved. Surprisingly, the fraction 10% is not affected by phylogenetic distance. These results support a selection-driven process that allows compensated amino acid substitutions to become rapidly fixed in taxa with large populations.