Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy
Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy
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DOI：
10.1001/archopht.122.6.883
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发表时间：
2004-06-01
影响因子：
--
通讯作者：
Hankinson, SE
中科院分区：
文献类型：
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作者：
Cho, EY;Seddon, JM;Hankinson, SE
目的：研究摄入的抗氧化维生素和类胡萝卜素，以及水果和蔬菜的发展年龄相关性黄斑病变（ARM）。方法：我们进行了前瞻性的后续研究，女性在护士的健康研究和男性在卫生专业人员的后续研究。我们对77562名女性和40866名男性进行了随访，这些女性和男性至少50岁，并且在基线时没有被诊断为ARM或癌症，女性随访长达18年，男性随访长达12年。水果和蔬菜的摄入量进行了评估与验证半定量的食物频率问卷多达5次的女性和多达3次的男性在随访期间。共464个（329名女性和135名男性）早期ARM事件病例和316名在随访期间诊断出217例女性和99例男性新生血管性ARM病例，所有病例的视力丧失均为20/30或更差，主要是由于ARM。水果摄入量与新生血管ARM的风险呈负相关。与每天摄入少于1.5份水果的参与者相比，每天摄入3份或更多份水果的参与者的合并多变量相对风险为0.64（95%置信区间，0.44-0.93;趋势P值= 0.004）。结果在女性和男性中相似。然而，蔬菜，抗氧化维生素，或类胡萝卜素的摄入量没有强烈的早期或新生血管ARM.Conclusion相关：这些数据表明，水果摄入量的新生血管ARM. Conclusion的风险的保护作用。
Objective: To examine the intake of antioxidant vitamins and carotenoids as well as fruits and vegetables in relation to the development of age-related maculopathy (ARM).Methods: We conducted a prospective follow-up study of women in the Nurses' Health Study and men in the Health Professionals Follow-up Study. We followed 77 562 women and 40 866 men who were at least 50 years of age and had no diagnosis of ARM or cancer at baseline for up to 18 years for women and up to 12 years for men. Fruit and vegetable intakes were assessed with a validated semi-quantitative food-frequency questionnaire up to 5 times for women and up to 3 times for men during follow-up.Results: A total of 464 (329 women and 135 men) incident cases of early ARM and 316 (217 women and 99 men) cases of neovascular ARM, all with visual loss of 20/30 or worse due primarily to ARM, were diagnosed during follow-up. Fruit intake was inversely associated with the risk of neovascular ARM. Participants who consumed 3 or more servings per day of fruits had a pooled multivariate relative risk of 0.64 (95% confidence interval, 0.44-0.93; P value for trend = .004) compared with those who consumed less than 1.5 servings per day. The results were similar in women and men. However, intakes of vegetables, antioxidant vitamins, or carotenoids were not strongly related to either early or neovascular ARM.Conclusion: These data suggest a protective role for fruit intake on the risk of neovascular ARM.