Thioester-containing proteins and insect immunity
Thioester-containing proteins and insect immunity
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DOI：
10.1016/j.molimm.2003.10.010
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发表时间：
2004-02-01
影响因子：
3.6
通讯作者：
Levashina, EA
中科院分区：
文献类型：
--
作者：
Blandin, S;Levashina, EA
在这里，我们讨论了含有硫酯的蛋白质在昆虫先天免疫反应中的作用。TEP在果蝇和冈比亚按蚊中都是由多成员家族代表的。对该科的系统发育分析表明，在这两个双翅目物种中，由于对不同生态环境的具体适应，TEP的进化遵循独立的情景。对这两个相对简单、缺乏获得性免疫的模型系统的研究，可能会为这个重要蛋白质家族的进化起源和功能提供新的见解。(C)2003爱思唯尔有限公司。保留所有权利。
Here, we discuss the role of thioester-containing proteins in innate immune responses of insects. TEPs are represented by multi-member families both in the fruitfly, Drosophila melanogaster, and in the mosquito, Anopheles gambiae. Phylogenetic analysis of the family suggests that in these two dipteran species evolution of TEPs followed independent scenarios as a result of specific adaptation to distinct ecological environments. Research on these two relatively simple model systems, which lack adaptive immunity, may provide new insights into the evolutionary origins and functions of this important protein family. (C) 2003 Elsevier Ltd. All rights reserved.