Performance prediction of industrial centrifuges using scale-down models
Performance prediction of industrial centrifuges using scale-down models
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DOI：
10.1007/s00449-003-0328-y
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发表时间：
2004-12-01
影响因子：
3.8
通讯作者：
Hoare, M
中科院分区：
文献类型：
--
作者：
Boychyn, M;Yim, SSS;Hoare, M
计算流体动力学被用来模拟在多室转鼓离心机的进料区发现的高流动力，并在一个小的，高速旋转的圆盘装置重现这些。将该装置与按比例缩小的离心相连接，可以很好地评估各种连续流离心机（叠盘、多室离心杯、卡尔Powerfuge（TM））用于剪切敏感蛋白质沉淀的性能。至关重要的是，超缩小规模离心过程被证明是一个更准确的预测生产多室转杯性能比中试离心机。
Computational fluid dynamics was used to model the high flow forces found in the feed zone of a multichamber-bowl centrifuge and reproduce these in a small, high-speed rotating disc device. Linking the device to scale-down centrifugation, permitted good estimation of the performance of various continuous-flow centrifuges (disc stack, multichamber bowl, CARR Powerfuge (TM)) for shear-sensitive protein precipitates. Critically, the ultra scale-down centrifugation process proved to be a much more accurate predictor of production multichamber-bowl performance than was the pilot centrifuge.