SHORT CHAIN FATTY-ACIDS IN HUMAN LARGE-INTESTINE, PORTAL, HEPATIC AND VENOUS-BLOOD
SHORT CHAIN FATTY-ACIDS IN HUMAN LARGE-INTESTINE, PORTAL, HEPATIC AND VENOUS-BLOOD
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DOI：
10.1136/gut.28.10.1221
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发表时间：
1987-10-01
期刊：
影响因子：
24.5
通讯作者：
MACFARLANE, GT
中科院分区：
文献类型：
--
作者：
CUMMINGS, JH;POMARE, EW;MACFARLANE, GT
在人类结肠中碳水化合物发生微生物分解的证据已经通过测量短链脂肪酸（SCFA）浓度在大肠的所有区域的内容物和门静脉，肝脏和外周静脉血中获得的猝死受害者尸检死亡后4小时内。在13 ± 10 ℃时，末端回肠中的总SCFA浓度（mmol/kg）较低。6，但在结肠的所有区域都很高，范围为131. ±.盲肠9至80.+-。降结肠11处。还注意到支链脂肪酸的存在。在从盲肠到降结肠的远端，发现了从高到低的浓度的显著趋势。pH值也随5.6 ±. 0.2在盲肠中为6.6.+-。0.1在降结肠pH和SCFA浓度呈负相关。血液中的总SCFA（μ mol/l）为，门静脉375 ±。70，肝脏148。42和外围设备79。22.在所有样品中，乙酸盐是主要阴离子，但三种主要SCFA中的摩尔比从结肠内容物到门静脉血再到肝静脉发生变化，表明结肠上皮对丁酸盐的吸收更大，肝脏对丙酸盐的吸收更大。这些数据表明，大量的碳水化合物，可能还有蛋白质，发酵发生在人体大肠中，主要是在盲肠和升结肠，大肠可能在消化中发挥更大的作用，比以前归因于它。
Evidence for the occurrence of microbial breakdown of carbohydrate in the human colon has been sought by measuring short chain fatty acid (SCFA) concentrations in the contents of all regions of the large intestine and in portal, hepatic and peripheral venous blood obtained at autopsy of sudden death victims within four hours of death. Total SCFA concentration (mmol/kg) was low in the terminal ileum at 13 .+-. 6 but high in all regions of the colon ranging from 131 .+-. 9 in the caecum to 80 .+-. 11 in the descending colon. The presence of branched chain fatty acids was also noted. A significant trend from high to low concentrations was found on passing distally from caecum to descending colon. pH also changed with region from 5.6 .+-. 0.2 in the caecum to 6.6 .+-. 0.1 in the descending colon. ph and SCFA concentrations were inversely related. Total SCFA (.mu.mol/l) in blood was, portal 375 .+-. 70, hepatic 148 .+-. 42 and peripheral 79 .+-. 22. In all samples acetate was the principal anion but molar ratios in the three principal SCFA changed on going from colonic contents to portal blood to hepatic vein indicating greater uptake of butyrate by the colonic epithelium and propionate by the liver. These data indicate that substantial carbohydrate, and possibly protein, fermentation is occurring in the human large intestine, principally in the caecum and ascending colon and that the large bowel may have a greater role to play in digestion than has previously been ascribed to it.