Expression of multidrug-resistance P-glycoprotein (MDR1) in human brain tumors
Expression of multidrug-resistance P-glycoprotein (MDR1) in human brain tumors
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DOI：
10.1002/ijc.1306
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发表时间：
2001-07-01
影响因子：
6.4
通讯作者：
Beliveau, R
中科院分区：
文献类型：
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作者：
Demeule, M;Shedid, D;Beliveau, R
多药耐药性 (MDR) 与 P-糖蛋白 (P-gp) 的表达有关，P-糖蛋白是一种 ATP 依赖性转运蛋白，可将抗癌药物从细胞中排出。在本研究中，MDRI P-gp通过Western blot分析在60例人脑肿瘤中进行了免疫检测，包括脑膜瘤、神经鞘瘤、低级别胶质瘤（星形细胞瘤、毛细胞星形细胞瘤）和高级别胶质瘤（间变性星形细胞瘤、胶质母细胞瘤和间变性少突胶质细胞瘤），大多数原发性肿瘤样本的P-gp表达水平与正常脑组织相同，除了神经鞘瘤的水平降低了 65%，脑膜瘤的 10 个样本中有 7 个的水平高出 10 倍以上。黑色素瘤和肺腺癌脑转移中的 P-gp 水平分别比正常脑组织低 70% 和 95%。这些结果表明，大多数原发性脑肿瘤表达 MDRI P-gp，其在脑膜瘤中的高表达水平可能是此类脑肿瘤的标志。 (C) 2001 Wiley-Liss, Inc.
Multidrug resistance (MDR) is associated with the expression of P-glycoprotein (P-gp), an ATP-dependent transporter which expels anti-cancer drugs from cells. In the present study, MDRI P-gp was immunodetected by Western blot analysis in 60 human brain tumors, including meningiomas, schwannomas, low-grade gliomas (astrocytomas, pilocytic astrocytomas) and high-grade gliomas (anaplastic astrocytomas, glioblastomas and anaplastic oligodendrogliomas), Most samples from primary tumors expressed P-gp at the same levels as normal brain tissue except for schwannomas, in which levels were reduced by 65%, and meningiomas, in which levels were more than 10-fold higher in 7 of 10 samples. P-gp levels were 70% and 95% lower in brain metastases from melanomas and lung adenocarcinomas, respectively, than in normal brain tissue, These results indicate that the majority of primary brain tumors express MDRI P-gp and that its high expression levels in meningiomas may be a marker for this type of brain tumor. (C) 2001 Wiley-Liss, Inc.