Fast dixon whole-body MRI for detecting distant cancer metastasis: a preliminary clinical study
Fast dixon whole-body MRI for detecting distant cancer metastasis: a preliminary clinical study
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DOI：
10.1002/jmri.22815
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发表时间：
2012-02-01
影响因子：
4.4
通讯作者：
Madewell, John E.
中科院分区：
文献类型：
--
作者：
Costelloe, Colleen M.;Kundra, Vikas;Madewell, John E.
目的：评价快速Dixon全身（WB）磁共振成像（MRI）检测临床患者骨和肝转移的可行性，并与骨骼闪烁成像（SS）检测骨转移的性能进行比较，以bb10年随访为金标准。材料和方法：29例骨转移患者前瞻性行WB MRI和SS检查。WB MRI包括冠状位T2、轴向T1、静脉注射和不注射钆（包括三期肝脏序列）、轴向弥散加权成像，以及脊柱矢状面造影后T1加权成像。骨骼被分成16段。对其他图像不知情的审稿人识别出每个节段最多五个病变，并使用转移性疾病的五点置信度评分。使用McNemar试验比较敏感性和特异性。结果：WB MRI和SS检测骨转移的敏感性分别为70.8%和59.6% (P = 0.003)；特异性分别为89.1%和98.7% （P < 0.0001）。WB MRI检测到所有转移灶（n = 8）。一个局灶性结节增生在WB MRI上被归类为转移。结论：快速Dixon WB MRI在临床患者中是可行的，特异性高，对骨转移的检测比SS更敏感，并能检测肝脏转移。
Purpose: To evaluate the feasibility of fast Dixon whole-body (WB) magnetic resonance imaging (MRI) for detecting bone and liver metastasis in clinical patients and to compare its performance with skeletal scintigraphy (SS) for detecting bone metastases using reference imaging with >1 year follow-up as the gold standard.Materials and Methods: Twenty-nine patients with bone metastases prospectively underwent WB MRI and SS. WB MRI included coronal T2, axial T1 with and without intravenous gadolinium (including triphasic liver sequences), and axial diffusion-weighted imaging, plus spinal sagittal postcontrast T1-weighted images. The skeleton was divided into 16 segments. Reviewers blinded to other images identified up to five lesions per segment and rated them using a five-point confidence scale for metastatic disease. Sensitivities and specificities were compared using the McNemar test.Results: The sensitivity of WB MRI and SS in detecting bone metastases was 70.8% and 59.6% (P = 0.003), respectively; specificity was 89.1% and 98.7% (P < 0.0001). WB MRI detected all livers with metastases (n = 8). One focal nodular hyperplasia was classified as a metastasis on WB MRI.Conclusion: Fast Dixon WB MRI is feasible in clinical patients, highly specific, and more sensitive than SS in detecting bone metastases, and can detect metastases of the liver.