STRESS, LONELINESS, AND CHANGES IN HERPESVIRUS LATENCY
STRESS, LONELINESS, AND CHANGES IN HERPESVIRUS LATENCY
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DOI：
10.1007/bf00870312
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发表时间：
1985-09-01
影响因子：
3.1
通讯作者：
HOLLIDAY, JE
中科院分区：
文献类型：
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作者：
GLASER, R;KIECOLTGLASER, JK;HOLLIDAY, JE
本研究采用前瞻性设计，通过检测三种疱疹病毒（EB病毒、单纯疱疹病毒I型和巨细胞病毒）抗体水平的变化，研究考试压力和孤独对疱疹病毒潜伏期的影响。从49名一年级医学生中获得了三份血液样本，第一份样本在期末考试前1个月抽取，第二份在期末考试的第一天抽取，第三份在暑假结束后的第一周抽取。加州大学洛杉矶分校孤独量表的中位数分为高分孤独组和低分孤独组。所有三种疱疹病毒的抗体滴度在各采样点均发生了显著变化，在第三个（低应力）样本中发现了最低水平。高度孤独的受试者有显着较高的EBV抗体滴度比低孤独的受试者。这些数据表明，应激相关的免疫抑制可以显着调节疱疹病毒潜伏期。
Tihs study used a prospective design to examine the influence of examination stress and loneliness on herpesvirus latency as measured by changes in antibody levels to three herpesviruses, Epstein-Barr virus (EBV), Herpes simplex type I (HSV-1), and cytomegalovirus (CMV). Three blood samples were obtained from 49 first-year medical students, with the first sample drawn 1 month before final examinations, the second on the first day of final examinations, and the third during the first week after their return from summer vacation. A median split on the UCLA Lonliness Scale divided sujects into high- and low-scoring lonliness groups. There were significant changes in the antibody titers to all three herpesvirus across the sample points, with the lowest levels found in the third (low stress) sample. High-lonliness subjects had significantly higher EBV antibody titers than low-loneliness subjects. These data suggest that stress-related immunosuppression can significantly modulate herpesvirus latency.