Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice.
Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice.
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针对放射状胶质细胞的寨卡病毒垂直传播影响子代小鼠的皮层发育
DOI：
10.1038/cr.2016.58
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发表时间：
2016-06
期刊：
影响因子：
44.1
通讯作者：
Luo ZG
中科院分区：
文献类型：
--
作者：
Wu KY;Zuo GL;Li XF;Ye Q;Deng YQ;Huang XY;Cao WC;Qin CF;Luo ZG
最近在拉丁美洲发生的寨卡病毒（ZIKV）流行与新生儿小头症的显著增加同时发生。然而，母体寨卡病毒感染与胎儿大脑畸形之间的因果关系尚未得到牢固确立。在这里，我们展示了ZIKV在小鼠中的垂直传播和对胎儿大脑发育的显著影响。我们发现，妊娠小鼠腹腔注射当代ZIKV毒株可导致胎儿脑室背区放射状胶质细胞（RGs）感染，并导致胎儿皮质建立细胞显著减少。RGs是负责皮质发育的主要神经祖细胞。有趣的是，受感染的胎鼠表现出侧脑室腔减少，皮层表面积明显减少。因此，本研究支持了垂直传播寨卡病毒影响胎儿大脑发育的结论，并为评估潜在的治疗或预防策略提供了有价值的动物模型。
The recent Zika virus (ZIKV) epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the fetal brain has not been firmly established. Here we show a vertical transmission of ZIKV in mice and a marked effect on fetal brain development. We found that intraperitoneal (i.p.) injection of a contemporary ZIKV strain in pregnant mice led to the infection of radial glia cells (RGs) of dorsal ventricular zone of the fetuses, the primary neural progenitors responsible for cortex development, and caused a marked reduction of these cortex founder cells in the fetuses. Interestingly, the infected fetal mice exhibited a reduced cavity of lateral ventricles and a discernable decrease in surface areas of the cortex. This study thus supports the conclusion that vertically transmitted ZIKV affects fetal brain development and provides a valuable animal model for the evaluation of potential therapeutic or preventative strategies.