Assessment of the diurnal variations in urinary homovanillic and vanillylmandelic acid excretion for the diagnosis and follow-up of patients with neuroblastoma.
Assessment of the diurnal variations in urinary homovanillic and vanillylmandelic acid excretion for the diagnosis and follow-up of patients with neuroblastoma.
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评估尿液中高香草酸和香草扁桃酸排泄的昼夜变化，以用于神经母细胞瘤患者的诊断和随访。
DOI：
10.1016/s0009-9120(85)80104-1
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发表时间：
1985
影响因子：
2.8
通讯作者：
Krivit,W
中科院分区：
文献类型：
--
作者：
Tuchman,M;Robison,LL;Maynard,RC;Ramnaraine,ML;Krivit,W
本文研究了神经母细胞瘤患者和对照组尿高香草酸（HVA）和香草扁桃酸（VMA）的昼夜变化。比较了24小时内连续4次6小时尿液收集中的尿HVA和VMA水平。HVA和VMA水平以μg/mg尿肌酐（UCr）和mg/6 h标本表示。当以μg/mg UCr或mg/6 h表示时，未发现四个时间间隔之间的统计学显著变化。在一天中的不同时间段，HVA和VMA的排泄存在微小的变化，这是由于肾脏排泄的变化，而不是产生的变化。这项研究的结果表明，随机尿液样本应该与24小时收集的样本一样好，用于神经嵴肿瘤的诊断和随访。
The diurnal variation of urinary homovanillic acid (HVA) and vanillylmandelic acid (VMA) was studied in neuroblastoma patients and in a control group. Urinary HVA and VMA levels in four sequential 6-hour urine collections within a 24-hour period were compared. HVA and VMA levels were expressed in μg/mg of urinary creatinine (UCr) and in mg/6h specimens. No statistically significant variations between the four time intervals were found when expressed in μg/mg UCr or mg/6h. The small variations that exist in the excretion of HVA and VMA during different periods of the day are due to variations in renal excretion rather than variations in production. The results from this study indicate that a random urine sample should be as good as a 24-hour collection for diagnosis and follow-up of neural crest tumors.