Oxidative stress, nitric oxide, and diabetes.
Oxidative stress, nitric oxide, and diabetes.
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DOI：
10.1900/rds.2010.7.15
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Ghirlanda, Giovanni
中科院分区：
文献类型：
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作者：
Pitocco, Dario;Zaccardi, Francesco;Ghirlanda, Giovanni
近几十年来，氧化应激已成为大多数生物医学学科和多种临床研究的热点。越来越多的证据表明，氧化应激与糖尿病、肥胖症、癌症、衰老、炎症、神经退行性疾病、高血压、细胞凋亡、心血管疾病和心力衰竭的发病机制有关。基于这项研究，新兴的概念是，氧化应激是“最终共同途径”，通过它，一些疾病的危险因素发挥其有害作用。氧化应激导致细胞代谢和细胞间稳态的复杂失调。在这篇综述中，我们讨论了氧化应激在胰岛素抵抗和β细胞功能障碍的发病机制中的作用。这是2型糖尿病的病理生理学和糖尿病血管并发症的发病机制中最相关的两种机制，糖尿病血管并发症是糖尿病患者死亡的主要原因。
In the recent decades, oxidative stress has become focus of interest in most biomedical disciplines and many types of clinical research. Increasing evidence from research on several diseases show that oxidative stress is associated with the pathogenesis of diabetes, obesity, cancer, ageing, inflammation, neurodegenerative disorders, hypertension, apoptosis, cardiovascular diseases, and heart failure. Based on this research, the emerging concept is that oxidative stress is the "final common pathway", through which risk factors of several diseases exert their deleterious effects. Oxidative stress causes a complex dysregulation of cell metabolism and cell-cell homeostasis. In this review, we discuss the role of oxidative stress in the pathogenesis of insulin resistance and beta-cell dysfunction. These are the two most relevant mechanisms in the pathophysiology of type 2 diabetes, and in the pathogenesis of diabetic vascular complications, the leading cause of death in diabetic patients.