Design of an inversion center between two helical segments
Design of an inversion center between two helical segments
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DOI：
10.1021/ja0481981
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发表时间：
2004-08-18
影响因子：
15
通讯作者：
Huc, I
中科院分区：
文献类型：
--
作者：
Maurizot, V;Dolain, C;Huc, I
提出了一种新策略来控制两个折叠螺旋低聚物的相对方向，使它们偏离芳香族接头并具有相反的螺旋旋向性。两个螺旋之间的空间排斥是由于它们不能同时折叠且位于接头的同一侧的事实造成的。该概念使用 8-氨基-2-喹啉羧酸寡酰胺的螺旋构象得到验证，但它应该适用于许多寡聚物家族，并导致第一个设计的内消旋螺旋。
A new strategy is proposed to control the relative orientation of two folded helical oligomers in such a way that they diverge from an aromatic linker and have opposite helical handedness. Mutual steric exclusion between the two helices results from the fact that they cannot be at the same time folded and on the same side of the linker. The concept is validated using the helical conformations of oligoamides of 8-amino-2-quinolinecarboxylic acid, but it should be applicable to many families of oligomers and leads to the first designed meso-helices.