Solubilization of phloretin via steviol glycoside-based solid dispersion and micelles.
Solubilization of phloretin via steviol glycoside-based solid dispersion and micelles.
复制标题
DOI：
10.1016/j.foodchem.2019.125569
复制
发表时间：
2020-03
期刊：
影响因子：
8.8
通讯作者：
Fan Wang;Xiaonian Xiao;Yiting Yuan;Jing Liu;Yuezhen Liu;Xing Yi
中科院分区：
文献类型：
--
作者：
Fan Wang;Xiaonian Xiao;Yiting Yuan;Jing Liu;Yuezhen Liu;Xing Yi
在这项研究中，通过基于甜菊糖苷（STE）的胶束（MC）和固体分散体（SD）增强了根皮素（PT）的溶解度。通过计算机模拟、表征、与血清白蛋白（SA）的相互作用以及体外释放来研究其增溶机制及其增溶能力的差异。对于负载 PT 的 MC (STE-PT MC)，PT 被封装到液滴直径为 5 nm 的球形胶束的疏水核心中。对于负载 PT 的 SD (STE-PT SD)，PT 以非晶态完全分散在 STE 中。大多数PT直接溶解在水中，少数被STE胶束包裹。无定形状态与相对较大的胶束相结合，使得 STE-PT SD 具有高溶解能力。此外，STE-PT SD 的 PT 比 STE-PT MC 表现出更高的溶解速率和与 SA 更有效的相互作用。 PT 和 STE 之间没有发生不良的化学相互作用。
In this study, the solubility of phloretin (PT) was enhanced via steviol glycoside (STE)-based micelle (MC) and solid dispersion (SD). Computer simulation, characterization, interaction with serum albumin (SA) andin vitrorelease were carried out to investigate the solubilization mechanisms and the difference in their solubilization capacities. For PT-loaded MC (STE-PT MC), PT was encapsulated into the hydrophobic core of a spherical micelle with a droplet diameter of 5 nm. For PT-loaded SD (STE-PT SD), PT was completely dispersed with the amorphous state in STE. Most of those PTs were directly dissolved in water, and few were encapsulated by STE micelles. The amorphous state combined with relatively large micelles contributed to the high solubilization capacity of STE-PT SD. In addition, PT of STE-PT SD exhibited a higher dissolution rate and more effective interaction with SA than that of STE-PT MC. No undesirable chemical interaction between PT and STE occurred.