Bio-inspired Incrustation Interfacial Polymerization of Dopamine and Cross-linking with Gelatin toward Robust, Biodegradable Three-Dimensional Hydrogels
Bio-inspired Incrustation Interfacial Polymerization of Dopamine and Cross-linking with Gelatin toward Robust, Biodegradable Three-Dimensional Hydrogels
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DOI：
10.1021/acs.langmuir.1c00364
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发表时间：
2021-05-05
期刊：
影响因子：
3.9
通讯作者：
Yabu, Hiroshi
中科院分区：
文献类型：
--
作者：
Abe, Hiroya;Yabu, Hiroshi
在自然界中，漆酶催化酚类化合物与氧气的反应，在昆虫和植物上产生称为角质层的硬化表面。受这一自然过程的启发，本工作研究了由多巴胺和明胶合成的稳健的、可生物降解的水凝胶。这种凝胶是通过将溶解在水中的多巴胺氧化而获得的，之后所得的醌化合物自动进行自聚合。氧化的多巴胺随后与明胶发生席夫碱和迈克尔加成反应，使得暴露的明胶表面交联以产生连续的硬化水凝胶膜。由于明胶随着温度的变化在溶胶和凝胶状态之间转变，因此可以从凝胶状态获得二维和三维结构。这种受生物启发的界面交联反应提供了形成复杂形态的简单方法，并代表了用于生物应用的有前途的技术。
In nature, laccase enzymatically catalyzes the reaction of phenolic compounds with oxygen to produce hardened surfaces known as cuticles on insects and plants. Inspired by this natural process, the present work investigated a robust, biodegradable hydrogel synthesized from dopamine and gelatin. This gel is obtained by the oxidation of dopamine dissolved in water, after which the resulting quinone compound automatically undergoes self-polymerization. The oxidized dopamine subsequently undergoes Schiff base and Michael addition reactions with gelatin, such that the exposed gelatin surface cross-links to generate a continuous hardened hydrogel film. Because gelatin transitions between sol and gel states with changes in temperature, two- and three-dimensional structures could be obtained from the gel state. This bio-inspired interfacial cross-linking reaction provides a simple means of forming complex morphologies and represents a promising technique for bio-applications.