Emerging HxNy Influenza A Viruses
Emerging HxNy Influenza A Viruses
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DOI：
10.1101/cshperspect.a038406
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发表时间：
2022-02-01
影响因子：
5.4
通讯作者：
Gao, George F.
中科院分区：
文献类型：
--
作者：
Liu, William J.;Wu, Yan;Gao, George F.
甲型流感病毒的不同亚型（被称为“HxNy”）的不断出现和重新出现是通过病毒基因组重组介导的，导致季节性流行、偶发大流行和人畜共患暴发。我们总结并讨论了历史上人类大流行 HxNy 病毒的特征以及野鸟、哺乳动物和活禽市场中 HxNy 的不同亚型。此外，我们从Hx的受体结合、Ny的抑制剂结合特异性和耐药特征以及基因片段的匹配等角度总结了新出现的传染性HxNy流感病毒的关键分子特征。我们的工作增强了我们对新型重配流感病毒对公共卫生的潜在威胁的了解，并为有效预防、控制和研究这种病原体提供了建议。
The continuous emergence and reemergence of diverse subtypes of influenza A viruses, which are known as "HxNy" and are mediated through the reassortment of viral genomes, account for seasonal epidemics, occasional pandemics, and zoonotic outbreaks. We summarize and discuss the characteristics of historic human pandemic HxNy viruses and diverse subtypes of HxNy among wild birds, mammals, and live poultry markets. In addition, we summarize the key molecular features of emerging infectious HxNy influenza viruses from the perspectives of the receptor binding of Hx, the inhibitor-binding specificities and drug-resistance features of Ny, and the matching of the gene segments. Our work enhances our understanding of the potential threats of novel reassortant influenza viruses to public health and provides recommendations for effective prevention, control, and research of this pathogen.