Mathematical models of hierarchically structured cell populations under equilibrium with application to the epidermis
Mathematical models of hierarchically structured cell populations under equilibrium with application to the epidermis
复制标题
平衡状态下分层结构细胞群的数学模型应用于表皮
DOI：
10.1046/j.1365-2184.2003.00257.x
复制
发表时间：
2003
影响因子：
8.5
通讯作者：
N. Savill
中科院分区：
文献类型：
--
作者：
N. Savill
抽象的。在表皮的萌发区室中有三类角质形成细胞-干细胞、过渡扩增细胞和有丝分裂后细胞。他们的人口结构是有等级的。这意味着干细胞分化为转运扩增细胞，经过几轮分裂后，成为有丝分裂后的细胞。细胞的出生、分化、死亡和迁移过程影响着萌发区室的组成和增殖速率。这些现象是量化的各种细胞动力学参数。在本文中，我们推导出方程，这些参数的不同模型的层次结构的细胞种群平衡。我们在模型中包括不对称和对称分裂，细胞周期时间的变化，细胞凋亡和运输代数的变化。我们的结论是，只有在细胞凋亡不可忽略的情况下，才需要考虑细胞周期时间的变化。如果它可以忽略不计，那么只需要平均细胞周期时间。不幸的是，从现有的实验数据中无法预测细胞凋亡的重要性。然而，其作用的强度取决于其他参数，特别是循环干细胞的分数。我们表明，过境世代的数量的变化可能有一个潜在的大的影响细胞出生率。我们还表明，细胞出生率并不直接取决于平均转运扩增细胞周期时间，只取决于平均干细胞周期时间。我们认为，“同质细胞群体”方程不应该被用来研究分层细胞群体已经在过去做的。最后，我们认为干细胞参数和转运扩增细胞参数不应该混为一谈。
Abstract. There are three categories of keratinocytes in the germinative compartment of the epidermis – stem, transit‐amplifying and post‐mitotic. Their population structure is hierarchical. This means that stem cells differentiate into transit‐amplifying cells which, after a few rounds of division, become post‐mitotic cells. The cell processes of birth, differentiation, death and migration affect the composition and proliferation rate of the germinative compartment. These phenomena are quantified by various cell kinetic parameters. In this paper we derive equations that relate these parameters for different models of hierarchically structured cell populations in equilibrium. We include in the models asymmetric and symmetric division, variations in cell‐cycle times, apoptosis and variation in the number of transit generations. We conclude that variation in cell‐cycle times need only be considered if apoptosis is not negligible. If it is negligible, then only average cell‐cycle times are needed. Unfortunately, it is impossible to predict the importance of apoptosis from the available experimental data. However, the strength of its effect is determined by the other parameters, especially the fraction of cycling stem cells. We show that variation in the number of transit generations can have a potentially large effect on cell birth rate. We also show that cell birth rate does not directly depend on the mean transit‐amplifying cell‐cycle time, only on the mean stem cell‐cycle time. We argue that ‘homogeneous cell population’ equations should not be used to study hierarchical cell populations as has been done in the past. Finally we argue that stem cell parameters and transit‐amplifying cell parameters should not be lumped together.
培养的人表皮角质形成细胞复制群体的异质性。
DOI：
10.1111/j.1432-0436.1986.tb00394.x
发表时间：
1986
期刊：
Differentiation; research in biological diversity
影响因子：
--
作者：
Albers,KM;Setzer,RW;Taichman,LB
通讯作者：
Taichman,LB