Anterior parietal cortical response to tactile and skin-heating stimuli applied to the same skin site.
Anterior parietal cortical response to tactile and skin-heating stimuli applied to the same skin site.
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前顶叶皮质对应用于同一皮肤部位的触觉和皮肤加热刺激的反应。
DOI：
10.1152/jn.1996.75.6.2662
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Whitsel,BL
中科院分区：
文献类型：
--
作者：
Tommerdahl,M;Delemos,KA;VierckJr,CJ;Favorov,OV;Whitsel,BL
1.用光学内信号成像和细胞外微电极记录方法研究了麻醉松鼠猴顶叶前皮层对皮肤刺激的反应。2.无害的机械刺激（振动触觉或皮肤轻敲）的对侧径向趾间垫伴随着减少反射率（在833 nm）在部门的cytoarchitectonic地区3b和1。这种内在信号与以前的感受野映射研究所示的区域登记，以接收来自径向趾间垫的低阈值机械感受器输入。3.皮肤加热刺激施加到对侧的径向指间垫与固定探头/热电极诱发没有可辨别的内在信号在区域3b和1，但诱发的信号在区域3a的外切部分。区域3a对使用固定探头/热电极的皮肤加热作出响应的区域与区域3b和区域1相邻，区域3b和区域1响应于相同皮肤部位的振动触觉刺激而产生固有信号。皮肤加热与固定探头/热电极也诱发内在的信号在区域4和2的区域相邻的区域3b/1的区域激活的对侧径向趾间垫的振动触觉刺激。4.在区域3a中通过对侧桡趾间垫的一系列加热刺激（使用固定探针/热电极）诱发的固有信号随着重复刺激（表现出缓慢的时间总和）的幅度逐渐增加，并在重复刺激终止后的较长时间内保持在刺激前水平以上。5.用探头/热电极维持在37 ℃或52 ℃，对侧桡侧趾间垫施加短暂的机械刺激（“轻拍”），伴随着区域3a和区域3b/1中固有信号的发展。对于52 ° C刺激，区域3a中的固有信号大于由37 ° C刺激诱发的相应信号，并且区域3b/1中的固有信号小于由37 ° C刺激诱发的相应信号。6.在用固定探针/热电极施加到对侧桡骨趾间垫的重复加热刺激期间，记录3a区神经元的尖峰放电活动。与重复加热同一皮肤部位引起的区域3a内在信号一样，区域3a神经元锋电位放电活动也表现出缓慢的时间总和和刺激后反应持续性。7.实验结果表明：（1）在前顶叶皮层处理皮肤加热刺激的主导作用，和（2）前顶叶对疼痛和振动触觉刺激的反应之间存在抑制性相互作用，这与最近对人类受试者的皮层成像和心理物理学研究中所证明的一致。
1. The response of anterior parietal cortex to skin stimuli was evaluated with optical intrinsic signal imaging and extracellular microelectrode recording methods in anesthetized squirrel monkeys. 2. Nonnoxious mechanical stimulation (vibrotactile or skin tapping) of the contralateral radial interdigital pad was accompanied by a decrease in reflectance (at 833 nm) in sectors of cytoarchitectonic areas 3b and 1. This intrinsic signal was in register with regions shown by previous receptive field mapping studies to receive low-threshold mechanoreceptor input from the radial interdigital pad. 3. A skin-heating stimulus applied to the contralateral radial interdigital pad with a stationary probe/thermode evoked no discernable intrinsic signal in areas 3b and 1, but evoked a signal within a circumscribed part of area 3a. The region of area 3a responsive to skin heating with the stationary probe/thermode was adjacent to the areas 3b and 1 regions that developed an intrinsic signal in response to vibrotactile stimulation of the same skin site. Skin heating with a stationary probe/thermode also evoked intrinsic signal in regions of areas 4 and 2 neighboring the area 3b/1 regions activated by vibrotactile stimulation of the contralateral radial interdigital pad. 4. The intrinsic signal evoked in area 3a by a series of heating stimuli to the contralateral radial interdigital pad (applied with a stationary probe/thermode) increased progressively in magnitude with repeated stimulation (exhibited slow temporal summation) and remained above prestimulus levels for a prolonged period after termination of repetitive stimulation. 5. Brief mechanical stimuli (,taps”) applied to the contralateral radial interdigital pad with a probe/thermode maintained either at 37 degrees C or at 52 degrees C were accompanied by the development of an intrinsic signal in both area 3a and areas 3b/1. For the 52 degrees C stimulus, the area 3a intrinsic signal was larger and the intrinsic signal in areas 3b/1 smaller than the corresponding signals evoked by the 37 degrees C stimulus. 6. Spike discharge activity was recorded from area 3a neurons during a repetitive heating stimulus applied with a stationary probe/ thermode to the contralateral radial interdigital pad. Like the area 3a intrinsic signal elicited by repetitive heating of the same skin site, the area 3a neuron spike discharge activity also exhibited slow temporal summation and poststimulus response persistence. 7. The experimental findings suggest 1) a leading role for area 3a in the anterior parietal cortical processing of skin-heating stimuli, and 2) the presence of inhibitory interactions between the anterior parietal responses to painful and vibrotactile stimuli consistent with those demonstrated in recent cortical imaging and psychophysical studies of human subjects.