Duodenal rather than antral motility contractile parameters correlate with symptom severity in gastroparesis patients
Duodenal rather than antral motility contractile parameters correlate with symptom severity in gastroparesis patients
复制标题
DOI：
10.1111/nmo.12496
复制
发表时间：
2015-03-01
影响因子：
3.5
通讯作者：
Kuo, B.
中科院分区：
文献类型：
--
作者：
Barshop, K.;Staller, K.;Kuo, B.
BackgroundStudies of symptomatic gastroparetics consistently find poor correlation with gastric emptying. We hypothesized that concomitant small bowel dysmotility may play a role in symptom causation in gastroparesis and sought to test this hypothesis by using wireless motility capsule (WMC) testing to simultaneously measure antral and duodenal area under pressure curve (AUC) in patients with delayed gastric emptying.MethodsUsing a cohort from a multicenter clinical trial and a separate tertiary clinical database, we identified gastroparetics that underwent concurrent WMC testing and completed the Gastroparesis Cardinal Symptom Index, a validated questionnaire. Our study included 35 gastroparetics defined by a gastric emptying time (GET) 5h. Antral and duodenal AUC were assessed at 1-h windows pre-GET and post-GET, respectively.Key ResultsWe found moderate correlations between duodenal AUC and symptom severity in the combined cohort (n=35; R=-0.42; p=0.01; 95% CI -0.7, -0.1). Removing patients with colonic delay resulted in a stronger correlation of duodenal AUC to symptom severity (n=21; R=-0.63; p
