Molecular genetics of papillary thyroid carcinoma: great expectations...
Molecular genetics of papillary thyroid carcinoma: great expectations...
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DOI：
10.1590/s0004-27302007000500002
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发表时间：
2007-07-01
期刊：
影响因子：
--
通讯作者：
Sobrinho-Simões, Manuel
中科院分区：
文献类型：
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作者：
Trovisco, Vítor;Soares, Paula;Sobrinho-Simões, Manuel
甲状腺乳头状癌（PTC）是最常见的内分泌癌类型，在最近的流行病学调查中，是发病率不断上升的人类癌症类型之一。尽管大多数患者的预后良好，生存率较长，但有些肿瘤表现出侵袭性，并可能发展为高度侵袭性和致命性的甲状腺间变性癌。近年来，在PTC的分子特征方面取得了一些进展，特别是在这种类型癌症的组织型多样性背后的遗传改变方面。这适用于核DNA以及线粒体DNA的改变。在这篇综述中，我们总结了PTC的遗传特征的最新研究结果，特别强调基因型-表型协会，预后的影响，以及新发现的遗传标记的诊断和治疗价值。
Papillary thyroid carcinoma (PTC) is the most prevalent type of endocrine cancer and, in recent epidemiological surveys, one of the types of human cancer whose incidence is growing. Despite the favourable outcome and long survival rates of most patients, some tumours display an aggressive behaviour and may progress to the highly aggressive and lethal, anaplastic thyroid carcinoma. In recent years, several progresses have been made on the molecular characterization of PTC, in general, and in the genetic alterations underlying the histotype diversity of this type of cancer, in particular. This holds true regarding alterations on nuclear DNA as well as mitochondrial DNA. In this review we have summarized the most recent findings in the genetic characterization of PTC, giving a particular emphasis to the genotype-phenotype associations, the prognosis implications, and the diagnostic and therapeutic value of the newly identified genetic markers.