Time-efficient determination of spin compartments by time-encoded pCASL T2-relaxation-under-spin-tagging and its application in hemodynamic characterization of the cerebral border zones
Time-efficient determination of spin compartments by time-encoded pCASL T2-relaxation-under-spin-tagging and its application in hemodynamic characterization of the cerebral border zones
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DOI：
10.1016/j.neuroimage.2015.08.025
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发表时间：
2015-12-01
期刊：
影响因子：
5.7
通讯作者：
van Osch, Matthias J. P.
中科院分区：
文献类型：
--
作者：
Schmid, Sophie;Teeuwisse, Wouter M.;van Osch, Matthias J. P.
关于穿过血脑屏障的水运输的信息可以根据动脉自旋标记（ASL）信号的T-2来确定。然而，使用多个反转时间的单独采集的当前方法对于临床（研究）应用来说太耗时。本研究的目的是通过将其与时间编码伪连续ASL（te-pCASL）相结合来提高该方法的时间效率。此外，在健康的年轻志愿者的大脑中的边界区区域的血流动力学特性的特点作为一个例子application. Te-pCASL的使用，而不是多TI pCASL显着减少了总的扫描时间，同时提供了更高的时间分辨率。在大脑中动脉和大脑后动脉的血流区域中，边缘区的脑血流量（CBF）明显低于中央区。边缘区区域的动脉通过时间（ATT）几乎是中部区域的两倍（p < 0.05），后部的平均延迟为382 ms，MCA血流区域的平均延迟为539 ms。当对ATT进行修正时，边界区与中心区相比，T-2随时间的变化没有显著差异。总之，te-pCASL-TRUST提供了一种根据T-2区分尾旋舱的时间有效的方法。边境地区的ATT明显长于中部地区。然而，从动脉到组织隔室的标记交换似乎以相似的速率进行。(C)2015 Elsevier Inc. All rights reserved.
Information on water-transport across the blood-brain barrier can be determined from the T-2 of the arterial spin labeling (ASL) signal. However, the current approach of using separate acquisitions of multiple inversion times is too time-consuming for clinical (research) applications. The aim of this study was to improve the time-efficiency of this method by combining it with time-encoded pseudo-continuous ASL (te-pCASL). Furthermore, the hemodynamic properties of the border zone regions in the brains of healthy, young volunteers were characterized as an example application.The use of te-pCASL instead of multi-TI pCASL significantly reduced the total scan duration, while providing a higher temporal resolution. A significantly lower cerebral blood flow (CBF) was found in the border zone regions compared with the central regions in both the posterior and the middle cerebral artery (MCA) flow territory. The arterial transit time (ATT) was almost two times longer in the border zone regions than in the central regions (p < 0.05), with an average delay in ATT of 382 ms in the posterior and 539 ms in the MCA flow territory. When corrected for the ATT, the change in T-2 over time was not significantly different for the border zones as compared to the central regions.In conclusion, te-pCASL-TRUST provided a time-efficient method to distinguish spin compartments based on their T-2. The ATT in the border zone is significantly longer than in the central region. However, the exchange of the label from the arterial to the tissue compartment appears to be at a similar rate. (C) 2015 Elsevier Inc. All rights reserved.