Nonsuppressible insulin-like activity (NSILA). II. Regulation of serum concentrations by growth hormone and insulin.
Nonsuppressible insulin-like activity (NSILA). II. Regulation of serum concentrations by growth hormone and insulin.
复制标题
不可抑制的胰岛素样活性（NSILA）。
DOI：
10.1210/jcem-46-4-672
复制
发表时间：
1978
期刊：
影响因子：
--
通讯作者：
C. J. Johnson
中科院分区：
文献类型：
--
作者：
U. Heinrich;D. Schalch;J. Koch;C. J. Johnson
通过采用前一篇论文中描述的新的竞争性蛋白结合测定法，在正常个体和患有 GH 分泌障碍的患者中，在基础和改变的碳水化合物代谢条件下，测量了被指定为不可抑制的胰岛素样活性 (NSILA) 的生长调节素的血清水平。此外，已在多种实验动物（小鼠、大鼠、兔、狗和羊）中测定了血清 NSILA 水平。 11 名肢端肥大症患者的平均 (± SEM) 水平 (1136 ± 60/μU/ml) 显着高于 14 名正常受试者 (836 ± 60/μU/ml) (P < 0.001)，而 8 名垂体功能减退患者的平均水平 (408 ± 30 μU/ml) 显着较低 (P < 0.001)，这证明血清 NSILA 是 GH 依赖性的。 21 μU/ml)。此外，对三名垂体功能低下患者施用人 GH 后，平均 NSILA 水平从基线 409 ± 108 /μU/ml 升至 628 ± 48 μU/ml。血清 NSILA 水平并未因胰岛素引起的低血糖而显着改变...
By employing a new competitive proteinbindingassay described in the previous paper, serum levels of the somatomedin designated as nonsuppressible insulin-like activity (NSILA) have been measured in normal individuals and patients with disorders of GH secretion, both under basal and altered conditions of carbohydrate metabolism. In addition, serum NSILA levels have been determined in several species of laboratory animals (mouse, rat, rabbit, dog, and sheep). Evidence that serum NSILA is GH-dependent is provided by the finding that the mean (± SEM) level in 11 acromegalics (1136 ± 60/μU/ml) is significantly higher (P < 0.001) and the mean level in 8 hypopituitary patients (408 ± 30 μU/ml) is significantly lower (P < 0.001) than that in 14 normal subjects (836 ± 21 μU/ml).Also, after the administration of human GH to three hypopituitary patients, the mean NSILA level rose from a baseline of 409 ± 108 /μU/ml to 628 ± 48 μU/ml. Serum NSILA levels were not significantly changed either by insulin-induced hypogly...