The effects of cocaine on nonhuman primate brain function are age dependent
The effects of cocaine on nonhuman primate brain function are age dependent
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DOI：
10.1111/j.1749-6632.1998.tb08232.x
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Morris, P
中科院分区：
文献类型：
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作者：
Paule, MG;Gillam, MP;Morris, P
急性静脉（i. v.）用1.5、3、10-11日龄恒河猴研究了可卡因（COC）对几种复杂脑功能的影响。受试者进行了几个操作性任务（食物），用于模型学习，短期记忆，颜色和位置的歧视，和动机，这些任务的性能中断被用来量化药物的效果。药物效应与年龄有关：最年轻的受试者比最年长的受试者敏感性低3至10倍。假设观察到的可卡因的行为效应主要是通过其与多巴胺（DA）系统的相互作用引起的，随着年龄的增长，其影响的敏感性的变化可能是DA系统的功能状态的反映。这些数据，沿着DA转运蛋白水平的初步数据，表明年龄相关的可卡因敏感性差异在于iu，或“下游”，多巴胺受体。
The effects of acute intravenous (i.v.) cocaine (COC) on several complex brain functions were studied in rhesus monkeys at 1.5, 3 anti 10-11 pars of age. Subjects performed several operant tasks (for food) that were used to model learning, short-term memory, color and position discrimination, and motivation, and disruption of performance of these tasks was used to quantitate drug effect. Drug effects were age dependent: The youngest subjects were 3 to 10 times less sensitive than the oldest. Presuming the observed behavioral effects of cocaine were caused primarily via its interaction with dopamine (DA) systems, changes in sensitivity to its effects with age are likely a reflection of the functional status of the DA system. These data, along with preliminary data on levels of DA transporters, suggest that the age-related differences in sensitivity to cocaine lie iu, or 'downstream' from, the dopamine receptor.