How nutritional status signalling coordinates metabolism and lignocellulolytic enzyme secretion
How nutritional status signalling coordinates metabolism and lignocellulolytic enzyme secretion
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DOI：
10.1016/j.fgb.2014.06.012
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发表时间：
2014-11-01
影响因子：
3
通讯作者：
Goldman, Gustavo Henrique
中科院分区：
文献类型：
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作者：
Brown, Neil Andrew;Ries, Laure Nicolas Annick;Goldman, Gustavo Henrique
木质纤维素植物生物质作为绿色化学品和生物燃料生产的丰富的可再生原料的利用受到其难降解性质的抑制。在环境中，木质纤维素分解真菌天然地能够将植物生物质分解成可利用的生物质。然而，在工业背景下，木质纤维素分解酶生产的低效率阻碍了绿色技术的实施。这种低效率的主要原因之一是通过碳分解代谢物抑制对木质纤维素分解酶的严格转录控制。真菌通过检测细胞内和细胞外的营养信号来协调代谢、蛋白质合成和分泌与细胞能量状态。因此，增强对参与调节木质纤维素分解酶的转录、翻译和分泌的信号和信号传导途径的理解具有极大的生物技术兴趣。这篇比较综述介绍了营养传感途径如何调节碳分解代谢物的阻遏，代谢和利用替代碳源的酿酒酵母和子囊菌真菌。(C)2014爱思唯尔公司All rights reserved.
The utilisation of lignocellulosic plant biomass as an abundant, renewable feedstock for green chemistries and biofuel production is inhibited by its recalcitrant nature. In the environment, lignocellulolytic fungi are naturally capable of breaking down plant biomass into utilisable saccharides. Nonetheless, within the industrial context, inefficiencies in the production of lignocellulolytic enzymes impede the implementation of green technologies. One of the primary causes of such inefficiencies is the tight transcriptional control of lignocellulolytic enzymes via carbon catabolite repression. Fungi coordinate metabolism, protein biosynthesis and secretion with cellular energetic status through the detection of intra- and extra-cellular nutritional signals. An enhanced understanding of the signals and signalling pathways involved in regulating the transcription, translation and secretion of lignocellulolytic enzymes is therefore of great biotechnological interest. This comparative review describes how nutrient sensing pathways regulate carbon catabolite repression, metabolism and the utilisation of alternative carbon sources in Saccharomyces cerevisiae and ascomycete fungi. (C) 2014 Elsevier Inc. All rights reserved.