Rat skeletal muscle metabolism in experimental heart failure: effects of physical training.
Rat skeletal muscle metabolism in experimental heart failure: effects of physical training.
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实验性心力衰竭中的大鼠骨骼肌代谢：体育训练的影响。
DOI：
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
B. Rajagopalan
中科院分区：
文献类型：
--
作者：
F. Brunotte;Campbell H. Thompson;S. Adamopoulos;Andrew J.S. Coats;John Unitt;D. Lindsay;L. Kaklamanis;G. Radda;B. Rajagopalan
慢性心力衰竭存在骨骼肌代谢异常。采用大鼠心肌梗死模型，研究了体育锻炼对心肌梗死后肌肉代谢的影响。冠状动脉结扎12周后Wistar大鼠进行31P磁共振波谱和酶分析。梗塞大鼠随机分为6周训练组和非训练组。在2hz的坐骨神经刺激下，采集小腿肌肉的光谱。纤维分型和酶分析对侧非刺激腿的肌肉进行。根据肺重量/体重将死后大鼠分为重度和中度心力衰竭。在200 g抽搐张力下，与其他组相比，未训练的严重心力衰竭组的磷酸肌酸和pH值明显降低。在严重心力衰竭的非训练组中，磷酸肌酸恢复半衰期明显更长，并且与肌肉中的柠檬酸合成酶活性相关。训练没有引起中度心力衰竭梗死动物体内酶活性的变化，但纠正了未训练的严重心力衰竭动物体内较低的柠檬酸合酶活性。这种肌肉代谢的正常化是通过训练实现的，而小腿肌肉质量没有任何变化，这使得萎缩不太可能是心力衰竭代谢变化的唯一原因。对患有严重心力衰竭的大鼠进行训练可以逆转骨骼肌代谢的异常，这意味着这些变化的病因是体力活动减少。
Skeletal muscle metabolic abnormalities exist in chronic heart failure. The influence of physical training on muscle metabolism after myocardial infarction was studied in a rat model. 31P magnetic resonance spectroscopy and enzyme assays were performed in Wistar rats 12 weeks after coronary artery ligation. Infarcted rats were allocated randomly to either 6 weeks of training or non-training. Spectra were collected from the calf muscles during sciatic nerve stimulation at 2 Hz. Fibre typing and enzymatic assays were performed on the muscles of the contralateral non stimulated leg. Post-mortem rats were also divided into severe and moderate heart failure according to the lung weight per body weight. At 200 g twitch tension, phosphocreatine and pH were found to be significantly lower in the non-trained severe heart failure group compared with the other groups. Phosphocreatine recovery half-time was significantly longer in the non-trained group with severe heart failure and correlated with the citrate synthase activity in the muscle. The training did not induce a change in the enzyme activities in the infarcted animals with moderate heart failure but did correct the lower citrate synthase activity in the non-trained severe heart failure animals. This normalization of muscle metabolism was achieved by training without any change in calf muscle mass, making atrophy unlikely to be the sole cause of the metabolic changes in heart failure. Training in rats with severe heart failure can reverse the abnormalities of skeletal muscle metabolism, implicating decreased physical activity in the aetiology of these changes.
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DOI：
10.1152/jappl.1988.65.3.1191
发表时间：
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期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
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DOI：
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期刊：
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