Programming placental nutrient transport capacity
Programming placental nutrient transport capacity
复制标题
DOI：
10.1113/jphysiol.2005.104141
复制
发表时间：
2006-04-01
影响因子：
5.5
通讯作者：
Constancia, M
中科院分区：
文献类型：
--
作者：
Fowden, AL;Ward, JW;Constancia, M
许多动物研究和人类流行病学调查结果表明，子宫内生长受损与以后生活中的生理异常有关，并将其与发育关键时期次优子宫内条件下的组织编程联系起来。然而，这些研究很少考虑胎盘对随后的成人表型的贡献。在哺乳动物中，宫内生长的主要决定因素是胎盘的营养供应，而胎盘的营养供应又取决于胎盘的大小、形态、血液供应和转运蛋白丰度，以及子宫胎盘组织对营养物质和激素的合成和代谢。本文综述了胎盘营养转移能力的调节，以及营养和糖皮质激素过度暴露对胎盘表型的潜在编程影响，特别强调Igf2基因在这些过程中的作用。
Many animal studies and human epidemiological findings have shown that impaired growth in utero is associated with physiological abnormalities in later life and have linked this to tissue programming during suboptimal intrauterine conditions at critical periods of development. However, few of these studies have considered the contribution of the placenta to the ensuing adult phenotype. In mammals, the major determinant of intrauterine growth is the placental nutrient supply, which, in turn, depends on the size, morphology, blood supply and transporter abundance of the placenta and on synthesis and metabolism of nutrients and hormones by the uteroplacental tissues. This review examines the regulation of placental nutrient transfer capacity and the potential programming effects of nutrition and glucocorticoid over-exposure on placental phenotype with particular emphasis on the role of the Igf2 gene in these processes.