Stability of the interface between neural tissue and chronically implanted intracortical microelectrodes.
Stability of the interface between neural tissue and chronically implanted intracortical microelectrodes.
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DOI：
10.1109/86.788468
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发表时间：
1999-09-01
期刊：
影响因子：
--
通讯作者：
Agnew, W F
中科院分区：
文献类型：
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作者：
Liu, X;McCreery, D B;Agnew, W F
神经组织和长期植入的微电极之间的界面的稳定性对于获得神经假体装置的可靠控制信号是非常重要的。稳定性对于大脑皮层的慢性微刺激也至关重要。然而，电极-组织界面的变化可由多种机制引起。在本研究中，将皮质内微电极阵列植入猫的十字周围回，并定期记录神经活动，持续数月。开发了一种基于聚类分析和峰间间隔分析的算法，将细胞外动作电位分类为单个单元。我们根据这些单位的波形以及它们对猫的躯体刺激或刻板动作的反应来追踪它们。我们的研究结果表明，植入后，电极-组织界面可能在前1-2周内每天变化，在1-2个月内每周变化，此后变得相当稳定。提出了一种稳定性指数来量化电极-组织界面的稳定性。对这种变化模式的原因进行了讨论。
The stability of the interface between neural tissue and chronically implanted microelectrodes is very important for obtaining reliable control signals for neuroprosthetic devices. Stability is also crucial for chronic microstimulation of the cerebral cortex. However, changes of the electrode-tissue interface can be caused by a variety of mechanisms. In the present study, intracortical microelectrode arrays were implanted into the pericruciate gyrus of cats and neural activities were recorded on a regular basis for several months. An algorithm based on cluster analysis and interspike interval analysis was developed to sort the extracellular action potentials into single units. We tracked these units based on their waveform and their response to somatic stimulation or stereotypical movements by the cats. Our results indicate that, after implantation, the electrode-tissue interface may change from day-to-day over the first 1-2 weeks, week-to-week for 1-2 months, and become quite stable thereafter. A stability index is proposed to quantify the stability of the electrode-tissue interface. The reasons for the pattern of changes are discussed.