Bioinspired cellular sheath-core electrospun non-woven mesh
Bioinspired cellular sheath-core electrospun non-woven mesh
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DOI：
10.1007/s42247-019-00043-7
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发表时间：
2019-06
影响因子：
3.8
通讯作者：
Hussain R. Rizvi;N. D'Souza;B. Ayre;D. Ramesh
中科院分区：
文献类型：
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作者：
Hussain R. Rizvi;N. D'Souza;B. Ayre;D. Ramesh
纤维对于生物医学应用很有价值。用作缝合线或网片时，越来越需要提供药物输送等功能。孔隙率代表高表面积体积结构。具有多孔层和无孔层的同轴光纤为光纤设计提供了新的设计框架，可以解决机械鲁棒性和传输现象的双重需求。利用聚合物在超临界二氧化碳中的优先溶解度，我们开发了一种基于多孔芯鞘纤维制造技术的生物相容性聚合物的新架构。选择聚己内酯作为CO2混溶相，聚己二酸对苯二甲酸丁酯(PBAT)作为不混溶相。使用准静态和动态加载研究了纤维的机械性能。 SEM 图像表明，在 CO2 暴露后，两种聚合物表面没有发生物理分离，这表明聚合物在芯和鞘的边界处成功融合。与原始 PCL 和 PBAT 相比，PCL 作为鞘和芯的拉伸强度分别增加了 650% 和 468%。同轴光纤fPCL(cPBAT)表面引入孔隙进一步提高了屈服强度，提高了40%。采用动态力学分析来分析纤维的粘弹性能。与原始 PCL 和 PBAT 相比，同轴光纤的储能模量和损耗模量在整个玻璃态、玻璃化转变和橡胶态区域表现出优异的模量，表明材料的弹性和粘性响应均得到增强。结果表明，一种不含挥发性有机溶剂的新方法可以操纵电纺纤维的横截面结构，并根据所需的应用调整机械性能。
Fibers are valuable to biomedical applications. Used as sutures or meshes, there is an increased dual need to provide functionality such as drug delivery. Porosity represents a high surface area to volume architecture. Coaxial fibers with porous and non-porous layers offer a new design framework for fiber design that can resolve dual needs of mechanical robustness with transport phenomena. Using preferential solubility of a polymer in supercritical CO2, we develop a new architecture using biocompatible polymers based on porous core-sheath fiber fabrication technique. Polycaprolactone was selected as the CO2miscible phase and Poly(butyrate adipate terephthalate)(PBAT) as the immiscible phase. The mechanical performance of the fibers was investigated using quasi static and dynamic loading. SEM images indicate no physical detachment of the two polymer surface after CO2exposure indicating a successful amalgamation of polymers at the boundary of core and sheath. PCL as a sheath and as a core showed an increase of 650% and 468% in tensile strength compared to pristine PCL and PBAT. Introduction of porosity on the surface of coaxial fiber fPCL(cPBAT) further enhanced the yield strength increases by 40%. Dynamic mechanical analysis was used to analyze the viscoelastic properties of the fibers. The storage and loss modulus for coaxial fibers shows superior modulus throughout the glassy, glass transition and rubbery region as compared to the pristine PCL and PBAT, showing enhancement in both the elastic and viscous response of the material. The results indicate a new approach that is free of volatile organic solvents to manipulate the architecture of the cross-section of the electrospun fiber and tailor mechanical properties to the required application.