REGULATION OF URINE MARKING IN MALE AND FEMALE MICE - EFFECTS OF SEX STEROIDS
REGULATION OF URINE MARKING IN MALE AND FEMALE MICE - EFFECTS OF SEX STEROIDS
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DOI：
10.1016/0018-506x(85)90006-6
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发表时间：
1985-01-01
影响因子：
3.5
通讯作者：
HAGIWARA, Y
中科院分区：
文献类型：
--
作者：
KIMURA, T;HAGIWARA, Y
研究了性类固醇对雄性、雌性和雄性化雌性小鼠尿标记活性的影响。通过将陶瓷管悬挂到隔离小鼠的饲养笼中来估计尿液标记，所述陶瓷管以水平行与钢棒连接。完整的男性表现出较高的标记活性，这是减少去势后。丙酸睾酮（TP）和苯甲酸雌二醇（EB）都能有效地恢复去势雄性的标记活性，而5-α-雌二醇（EB）能有效地恢复去势雄性的标记活性。双氢睾酮（DHT）没有任何刺激作用。完整的正常女性表现出相当低的标记活性和卵巢切除术进一步抑制它。TP和DHT增强标记卵巢切除女性，但EB恢复活性仅卵巢切除前的水平。在睾丸雄激素化的完整雌性中，标记活性远高于正常雌性。性腺切除和激素治疗引起的变化在这些女性的模式相似，在女性。卵巢切除降低了活性，TP和EB恢复了水平。显然，小鼠尿标记的两性异形主要由出生后早期的激素环境决定。激素控制的气味标记进行了讨论，在其他啮齿动物的研究。
Effects of sex steroids on urine-marking activity were studied in male, female and neonatally androgenated female mice. Urine marking was estimated by suspending ceramic tubes that were connected in a horizontal row with a steel rod into the home cage of an isolated mouse. Intact males showed high marking activity, which was diminished after castration. Both testosterone propionate (TP) and estradiol benzoate (EB) were effective in restoring the marking activity of castrated males, while 5-.alpha.-dihydrotestosterone (DHT) did not have any stimulative effects. Intact normal females showed quite low marking activity and ovariectomy further depressed it. TP and DHT enhanced the marking of ovariectomized females, but EB restored the activity only to the preovariectomy level. In intact females which were neonatally androgenized, the marking activity was much higher than that of normal females. The pattern of the change induced by gonadectomy and hormone treatment in these females resembled that in females. Ovariectomy reduced the activity and both TP and EB restored the level. Apparently, the sexual dimorphism in the urine marking in mice is primarily determined by hormonal environment during early postnatal age. Hormonal control of scent marking is discussed in relation to the studies in other rodents.