Stem Cells for the Treatment of Neurodegenerative Diseases
Stem Cells for the Treatment of Neurodegenerative Diseases
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DOI：
10.3390/molecules15106743
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发表时间：
2010-09-27
期刊：
影响因子：
4.6
通讯作者：
Zhang N
中科院分区：
文献类型：
--
作者：
Wu YP;Chen WS;Teng C;Zhang N
神经退行性疾病的特征在于参与网络的神经元的神经退行性变化或凋亡，导致永久性瘫痪和损伤部位以下的感觉丧失。细胞替代疗法为开发针对广谱人类神经系统疾病的潜在强大的新治疗策略提供了基础。近年来，神经元和神经胶质细胞已经成功地从干细胞中产生，并且研究人员已经进行了广泛的努力来开发基于干细胞的脑移植疗法。我们在这里回顾了以前发表的关于干细胞治疗神经退行性疾病的实验和临床前研究，并讨论了干细胞治疗神经系统疾病的临床前景。干细胞研究在基础和临床前环境中的稳定和坚实的进展应该支持开发基于干细胞的神经系统疾病细胞疗法的希望。
Neurodegenerative diseases are characterized by neurodegenerative changes or apoptosis of neurons involved in networks, leading to permanent paralysis and loss of sensation below the site of the injury. Cell replacement therapy has provided the basis for the development of potentially powerful new therapeutic strategies for a broad spectrum of human neurological diseases. In recent years, neurons and glial cells have successfully been generated from stem cells, and extensive efforts by investigators to develop stem cell-based brain transplantation therapies have been carried out. We review here notable previously published experimental and preclinical studies involving stem cell-based cell for neurodegenerative diseases and discuss the future prospects for stem cell therapy of neurological disorders in the clinical setting. Steady and solid progress in stem cell research in both basic and preclinical settings should support the hope for development of stem cell-based cell therapies for neurological diseases.
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影响因子：
6.1
作者：
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通讯作者：
Chen J
影响因子：
4.8
作者：
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Winkler, J
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14.5
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通讯作者：
De Strooper, Bart
影响因子：
5.2
作者：
Hedlund, Eva;Pruszak, Jan;Isacson, Ole
通讯作者：
Isacson, Ole