Lymphocyte-derived chemotactic factor synthesis in initial genital herpesvirus infection: correlation with lymphocyte transformation.
Lymphocyte-derived chemotactic factor synthesis in initial genital herpesvirus infection: correlation with lymphocyte transformation.
复制标题
初始生殖器疱疹病毒感染中淋巴细胞衍生的趋化因子合成：与淋巴细胞转化的相关性。
DOI：
10.1128/iai.30.1.110-116.1980
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发表时间：
1980
影响因子：
3.1
通讯作者：
Holmes,KK
中科院分区：
文献类型：
--
作者：
Rattray,MC;Peterman,GM;Altman,LC;Corey,L;Holmes,KK
本文研究了15例初发生殖器疱疹患者和10例对照者的淋巴细胞转化和淋巴细胞源性趋化因子对单纯疱疹病毒抗原的反应。患者接受频繁的生殖器检查、病毒培养和每周免疫学研究，为期11周。淋巴细胞源性趋化因子的产生在疾病的第1周达到最大，到第6周下降到对照水平。相比之下，淋巴细胞转化在第1周最低，在第4周达到最大值，并在第11周降至对照水平。淋巴细胞衍生的趋化因子的生产在第1周显着低于9例患者谁开发的体征或症状的全身疱疹感染比6谁有局部疾病。此外，在临床复发时，观察到这种淋巴因子的产生显著但短暂的下降。病毒特异性淋巴细胞转化与生殖器疼痛和病变的持续时间呈负相关，与全身体征或症状的存在无关。这些研究结果表明，在最初的生殖器疱疹感染的淋巴细胞转化的动力学和淋巴细胞衍生的趋化因子的生产是不同的，这种淋巴因子的产生是这种疾病的细胞免疫反应的早期组成部分。此外，足够的淋巴细胞衍生的趋化因子的生产可能是重要的限制单纯疱疹病毒的生殖器区域和防止疾病复发。
Lymphocyte transformation and production of lymphocyte-derived chemotactic factor in response to herpes simplex virus antigen were studied in 15 patients with initial genital herpes and 10 controls. The patients underwent frequent genital examinations, viral cultures, and weekly immunological studies for a period of 11 weeks. The production of lymphocyte-derived chemotactic factor was maximal in week 1 of the disease and declined to control levels by week 6. In contrast, lymphocyte transformation was lowest in week 1, reached a maximum by week 4, and declined to control levels by week 11. Production of lymphocyte-derived chemotactic factor in week 1 was significantly lower in nine patients who developed signs or symptoms of systemic herpes infection than in six who had localized disease. In addition, a marked but transient decline in the production of this lymphokine was observed in patients at the time of clinical recurrence. Virus-specific lymphocyte transformation correlated inversely with the duration of genital pain and lesions and did not correlate with the presence of systemic signs or symptoms. These findings indicate that during initial genital herpes infection the dynamics of lymphocyte transformation and those of lymphocyte-derived chemotactic factor production are different, and that the generation of this lymphokine is an early component of the cellular immune response in this disease. Furthermore, adequate produce of lymphocyte-derived chemotactic factor may be important in restricting herpes simplex virus to the genital area and preventing disease recurrence.