Acute-phase proteins during hemodialysis: correlations with serum interleukin-1 beta levels and different dialysis membranes.
Acute-phase proteins during hemodialysis: correlations with serum interleukin-1 beta levels and different dialysis membranes.
复制标题
血液透析期间的急性期蛋白：与血清白细胞介素 1 β 水平和不同透析膜的相关性。
作者：
E. Honkanen;C. Grönhagen;A. Teppo;C.P.J. Maury;Seppo Meri
观察了8例血液透析（HD）患者血清淀粉样蛋白A（SAA）、C反应蛋白（CRP）和白细胞介素1 β（IL-1 β）水平的变化。仅使用Biclidine透析液，并比较了三种不同的膜，Cuprophan（CU）、醋酸纤维素（CA）和聚甲基丙烯酸甲酯（PMMA）。每层膜的SAA水平均显着增加。有了CU，它们从4.0 +/- 2.0上升到（mg/l，平均值+/- SEM）至60 min时的9.6 +/- 2.8和240 min时的15.0 +/- 4.9。CA的值分别为3.8 +/- 2.1、15.3 +/- 5.6和23.8 +/- 3.9; PMMA分别为2.4 +/- 1.3、12.1 +/- 5.6和12.1 +/- 5.9。SAA的变化与透析期间体重减轻和血清白蛋白升高均无相关性。CRP值显示无显著变化。CU的IL-1 β水平从87 +/-18（ng/l）上升到60分钟时的155 +/-33，240分钟时的172 +/-47。CA的值分别为67 +/-14，198 +/-46，121 +/-23，PMMA的值分别为63 +/-13，246 +/-93，121 +/-23。和211 +/- 86。这些结果与膜对补体激活的影响无关。得出的结论是，HD期间细胞因子的释放显然会导致急性期蛋白的快速合成，这是炎症的标志。因此，SAA可用作HD治疗的生物相容性的一个指标。
The effects of hemodialysis (HD) on the levels of serum amyloid A (SAA), C-reactive protein (CRP) and interleukin-1 beta (IL-1 beta) were studied in 8 patients. Bicarbonate dialysate was used exclusively, and three different membranes, Cuprophan (CU), cellulose acetate (CA), and polymethylmetachrylate (PMMA) were compared. The SAA levels increased significantly with each membrane. With CU, they rose from 4.0 +/- 2.0 (mg/l, mean +/- SEM) to 9.6 +/- 2.8 at 60 min and to 15.0 +/- 4.9 at 240 min. The values with CA were 3.8 +/- 2.1, 15.3 +/- 5.6, and 23.8 +/- 3.9; and with PMMA 2.4 +/- 1.3, 12.1 +/- 5.6, and 12.1 +/- 5.9, respectively. The alterations of SAA neither correlated with the weight loss nor the increase of serum albumin during dialysis. The CRP values showed insignificant changes. The IL-1 beta levels rose with CU from 87 +/-18 (ng/l) to 155 +/- 33 at 60 min and to 172 +/- 47 at 240 min. With CA, the values were 67 +/- 14, 198 +/- 46, and 121 +/- 23, and with PMMA 63 +/- 13, 246 +/- 93, and 211 +/- 86, respectively. These results did not correlate with the effects of the membranes on complement activation. It is concluded that the release of cytokines during HD apparently leads to a rapid synthesis of acute-phase proteins as a sign of inflammation. Thus, SAA may be used as one indicator of the biocompatibility of HD treatment.