Overview of allergic mechanisms - Ebastine has more than an antihistamine effect
Overview of allergic mechanisms - Ebastine has more than an antihistamine effect
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DOI：
10.2165/00003495-199600521-00005
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发表时间：
1996-01-01
期刊：
影响因子：
11.5
通讯作者：
Bousquet, J
中科院分区：
文献类型：
--
作者：
Campbell, A;Michel, FB;Bousquet, J
组胺拮抗剂与局部类固醇是治疗变应性鼻炎的选择。许多组胺拮抗剂除了阻断组胺受体外，还表现出其他作用。在这项研究中，我们研究了依巴斯汀和卡巴斯汀对人分散的息肉细胞释放类二十烷酸和细胞因子的影响，以及这些化合物在过敏原攻击后对炎症介质释放到鼻灌洗液的影响。Ebastine阻断人鼻息肉细胞中抗ige诱导的前列腺素D-2 （PGD(2)）和白三烯C-4/D-4的释放（IC30值分别为2.57和9.6 mu mol/L），并抑制细胞因子的释放。Carebastine抑制PGD(2)的释放（IC30为8.14 mu mol/L），但对细胞因子的释放影响不大。当患者用过敏原进行鼻腔激发试验时，依巴斯汀显著增加了诱导过敏反应所需的花粉粒的平均数量。此外，该药抑制粒细胞-巨噬细胞集落刺激因子的释放，但对其他任何介质均无影响。
Histamine antagonists together with topical steroids are the treatment of choice in allergic rhinitis. Many of these histamine antagonists exhibit effects in addition to blockade of the histamine receptor. In this study we have investigated the effects of ebastine and carebastine on the release of eicosanoids and cytokines from human dispersed polyp cells and the effect of these compounds on the release of inflammatory mediators into nasal lavage fluid after allergen challenge. Ebastine was shown to block the release of anti-IgE-induced prostaglandin D-2 (PGD(2)) and leukotriene C-4/D-4 from human nasal polyp cells (IC30 values of 2.57 and 9.6 mu mol/L, respectively) and to inhibit the release of cytokines. Carebastine inhibited the release of PGD(2) (IC30 8.14 mu mol/L) but had little effect on cytokine release. When patients underwent nasal provocation tests with allergen, ebastine significantly increased the mean number of pollen grains required to induce an allergic response. In addition, the drug inhibited the release of granulocyte-macrophage colony-stimulating factor but had no effect on any other mediators measured.