Coverage of Sex Acts by Event-Driven Pre-exposure Prophylaxis: A Sub-Study of the ANRS IPERGAY Trial
Coverage of Sex Acts by Event-Driven Pre-exposure Prophylaxis: A Sub-Study of the ANRS IPERGAY Trial
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DOI：
10.1007/s10461-020-02890-6
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发表时间：
2020-04-29
影响因子：
4.4
通讯作者：
Molina, Jean-Michel
中科院分区：
文献类型：
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作者：
Bauer, Rebecca;Netzer, Emmanuelle;Molina, Jean-Michel
我们在ANRS Ipergay试验的开放标签阶段的54名参与者中评估了2个月内事件驱动暴露前预防（ED-PrEP）的性行为覆盖率。参与者收到一个电子监测系统设备，以记录瓶子的打开。自我问卷调查收集了关于PrEP摄入量和性行为的日常信息。还通过返回的药丸计数估计摄入量。性行为的完全覆盖被定义为在性行为前24小时内和性行为后48小时内至少服用一粒药丸。开瓶次数和返回的药丸数之间有很强的相关性（r =-0.92）。在研究期间，42名参与者（78%）练习ED-PrEP，12名（22%）每天练习PrEP，每周至少开瓶5天，无论他们的性活动如何。在154例报告的接受性肛交行为中，81%是无安全套的：其中，PrEP覆盖率很高：每天练习PrEP的人中有97%，使用ED-PrEP的人中有82%。
We assessed the coverage of sex acts by event-driven pre-exposure prophylaxis (ED-PrEP) over a 2-month period in 54 participants in the open label phase of the ANRS Ipergay trial. Participants received an electronic monitoring system device to record bottle openings. Self-questionnaires collected daily information on PrEP intake and sexual behavior. Intake was also estimated through returned pill counts. Full coverage of sex acts was defined as at least one pill taken both within 24 h before and within 48 h following sex. There was a strong correlation (r = - 0.92) between the number of bottle openings and returned pill counts. During the study, 42 participants (78%) practiced ED-PrEP and 12 (22%) daily PrEP with bottle openings at least 5 days/week whatever their sexual activity. Out of the 154 reported receptive anal sex acts, 81% were condomless: among them, PrEP coverage was hight: 97% among those practicing daily PrEP and 82% among those using ED-PrEP.