REGULATION OF EXPRESSION OF MAJOR OUTER SURFACE-PROTEINS IN BORRELIA-BURGDORFERI
REGULATION OF EXPRESSION OF MAJOR OUTER SURFACE-PROTEINS IN BORRELIA-BURGDORFERI
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DOI：
10.1128/iai.61.5.2207-2210.1993
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发表时间：
1993-05-01
影响因子：
3.1
通讯作者：
ROSA, PA
中科院分区：
文献类型：
--
作者：
MARGOLIS, N;ROSA, PA
我们的特点是伯氏疏螺旋体克隆（CA-11 2A），不合成的主要外表面蛋白，OspA和OspB。尽管osp操纵子是完整的并且能够表达，但是在该克隆中没有检测到mRNA转录物。这些结果表明，osp操纵子在B。burgdorferi克隆在转录水平上受到调控。
We have characterized a Borrelia burgdorferi clone (CA-11 2A) that does not synthesize the major outer surface proteins, OspA and OspB. While the osp operon is intact and capable of expression, no mRNA transcript is detectable in this clone. These results suggest that osp operon expression in the B. burgdorferi clone can be regulated at the level of transcription.