Back to the Basics: Cnidarians Start to Fire.
Back to the Basics: Cnidarians Start to Fire.
复制标题
DOI：
10.1016/j.tins.2016.11.005
复制
发表时间：
2017-02
影响因子：
15.9
通讯作者：
Yuste R
中科院分区：
文献类型：
--
作者：
Bosch TCG;Klimovich A;Domazet-Lošo T;Gründer S;Holstein TW;Jékely G;Miller DJ;Murillo-Rincon AP;Rentzsch F;Richards GS;Schröder K;Technau U;Yuste R
脊椎动物是在后生动物辐射的底部附近发散的前双侧动物，它们的神经系统结构简单，因此有很大的潜力告诉我们神经回路的基本结构和功能原理。不幸的是，到目前为止，蛇类动物对电生理和遗传技术相对棘手，因此在很大程度上被神经生物学家忽视了。然而，分子和成像方法的最新进展正在推动人们对蛇类神经系统的兴趣和研究的复兴。在这里，我们回顾了一些北极熊物种神经系统的现有知识，并建议研究人员应抓住这个机会，将这一门作为对神经科学具有重要基础和翻译意义的战略性实验系统进行研究。
The nervous systems of cnidarians, pre-bilaterian animals that diverged close to the base of the metazoan radiation, are structurally simple and thus have great potential to inform us about basic structural and functional principles of neural circuits. Unfortunately, cnidarians have thus far been relatively intractable to electrophysiological and genetic techniques and consequently have been largely passed over by neurobiologists. However, recent advances in molecular and imaging methods are fueling a renaissance of interest in and research into cnidarians nervous systems. Here, we review current knowledge on the nervous systems of some cnidarian species and propose that researchers should seize this opportunity and undertake the study of this phylum as strategic experimental systems with great basic and translational relevance for neuroscience.