CT Scans of Patients with 2019 Novel Coronavirus (COVID-19) Pneumonia
CT Scans of Patients with 2019 Novel Coronavirus (COVID-19) Pneumonia
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2019 年新型冠状病毒 (COVID-19) 肺炎患者的 CT 扫描
DOI：
10.7150/thno.45016
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发表时间：
2020-01-01
期刊：
影响因子：
12.4
通讯作者：
Liu, Jun
中科院分区：
文献类型：
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作者：
Zhao, Wei;Zhong, Zheng;Liu, Jun
理由：在中国，2019年新型冠状病毒（COVID-19）确诊病例的增长速度惊人。本研究的目的是总结我院新型冠状病毒肺炎（NCP）患者的结局。方法：在这项单中心研究中，我们回顾性纳入了2020年1月16日至2020年2月4日期间的118例新型冠状病毒感染病例。监测临床结果至2020年2月11日。在我院对NCP患者的预后进行分期总结。对临床治疗的三种反应进行定义和评价：1)良好，症状持续改善；2)一般，症状未改善或复发；3)病情不佳，症状加重。危险因素包括基础临床特征、CT影像特征以及与预后差/一般相关的随访CT变化（无变化、进展和改善）。结果：6例改善为非急诊型，2例维持原状，2例发展为致命型。从普通型组进展到急诊组13例，其中致死型3例，重症10例。42例（35.6%）患者出院，平均住院时间为9.5天（范围为4.0-15.0天）。因此，不同反应的人数为：良好反应组73例（紧急4例，无紧急69例），一般反应组28例（紧急3例，无紧急25例），差反应组17例（紧急3例，无紧急14例）。到目前为止，我们医院还没有病人死亡。CT扫描观察到的进展中位持续时间为6天（范围2-14天）。异常影像学表现的进展表明反应较差/一般，而CT表现的症状缓解表明反应良好。结论：多数病例为非急诊型，临床治疗效果良好。治疗过程中随访CT变化有助于评价新冠肺炎患者的治疗效果。
Rationale: The increasing speed of confirmed 2019 novel coronavirus (COVID-19) cases is striking in China. The purpose of this study is to summarize the outcomes of patients with novel COVID-19 pneumonia (NCP) at our institution. Methods: In this single-center study, we retrospectively included 118 cases of NCP, from January 16, 2020 to February 4, 2020. The clinical outcomes were monitored up to February 11, 2020. The outcomes of NCP patients were phase summarized at our institution. Three kinds of responses to clinical treatment were defined and evaluated: 1) good, symptoms continually improved; 2) fair, symptoms not improved or relapsed; 3) poor, symptoms aggravated. The risk factors, including basal clinical characteristics, CT imaging features, and follow-up CT changes (no change, progress, and improvement) related to poor/fair outcomes, were also investigated. Results: Six patients were improved to no-emergency type, 2 remained the same, and 2 progressed to fatal type. Besides, 13 patients progressed from the common type group to the emergency group (3 in fatal type and 10 in severe type). Forty-two (35.6%) patients were discharged with a median hospital stay of 9.5 days (range, 4.0-15.0 days). Thus, the numbers in different responses were, 73 patients in good response group (4 emergency cases, 69 no-emergency cases), 28 in fair response group (3 emergency cases, 25 no-emergency cases), and 17 in poor response group (3 emergency cases, 14 no-emergency cases). No patient has died in our hospital to date. The median duration of progress observed from CT scans was 6 days (range, 2-14 days). The progression in abnormal imaging findings indicate a poor/fair response, whereas the alleviated symptoms seen from CT suggest a good response. Conclusion: Most cases are no-emergency type and have a favorable response to clinical treatment. Follow-up CT changes during the treatment can help evaluate the treatment response of patients with NCP.