Cot-Side Electro-Encephalography and Interstitial Glucose Monitoring during Insulin-Induced Hypoglycaemia in Newborn Lambs
Cot-Side Electro-Encephalography and Interstitial Glucose Monitoring during Insulin-Induced Hypoglycaemia in Newborn Lambs
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DOI：
10.1159/000166847
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发表时间：
2009-01-01
期刊：
影响因子：
2.5
通讯作者：
Harding, Jane E.
中科院分区：
文献类型：
--
作者：
Harris, Deborah L.;Battin, Malcolm R.;Harding, Jane E.
背景：新生儿低血糖的最佳检测和管理方法仍不清楚。目的：我们试图证明在新生羔羊诱发低血糖期间，振幅积分脑电图监测仪是否可以检测到脑电图（EEG）变化，并确定在这种情况下连续测量的间质葡萄糖的准确性。方法：将针电极置于P3-P4、O1-O2 蒙太奇中。将间质葡萄糖传感器置于皮下。 30 分钟基线记录后，通过胰岛素输注诱发低血糖，并每 5 分钟监测一次血糖水平。调整输注量，每15分钟降低血糖水平0.5mmol/l，然后维持血糖水平
Background: The optimal approach to detection and management of neonatal hypoglycaemia remains unclear. Objectives: We sought to demonstrate whether electro-encephalography ( EEG) changes could be detected on the amplitude-integrated EEG monitor during induced hypoglycaemia in newborn lambs, and also to determine the accuracy of continuously measured interstitial glucose in this situation. Methods: Needle electrodes were placed in the P3-P4, O1-O2 montages. The interstitial glucose sensor was placed subcutaneously. After 30 min baseline recordings, hypoglycaemia was induced by insulin infusion and blood glucose levels were monitored every 5 min. The infusion was adjusted to reduce blood glucose levels by 0.5 mmol/l every 15 min and then maintain a blood glucose level