Modeling Leukemia with Human Induced Pluripotent Stem Cells.

Modeling Leukemia with Human Induced Pluripotent Stem Cells.
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用人类诱导多能干细胞模拟白血病。

DOI:
10.1101/cshperspect.a034868
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发表时间:
2019
影响因子:
5.4
通讯作者:
Papapetrou,EiriniP
Papapetrou,EiriniP
中科院分区:
医学2区
文献类型:
--
作者:
Papapetrou,EiriniP

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十多年前,人类体细胞被重新编程为诱导多能干细胞(iPSC),这为改变这项研究以及人类疾病的治疗带来了令人兴奋的前景。目前已针对包括恶性肿瘤在内的多种血液疾病创建了 iPSC 模型。在这里,我们讨论恶性疾病 iPSC 建模的实际问题,回顾最近的研究,并讨论 iPSC 模型提供的新机遇,以及其当前的局限性和未来发展的前景。
The reprogramming of human somatic cells into induced pluripotent stem cells (iPSCs) a little over a decade ago raised exciting prospects to transform the study and potentially also the therapy of human diseases. iPSC models have now been created for a multitude of hematologic diseases, including malignancies. Here we discuss practical aspects of iPSC modeling of malignant diseases, review recent studies, and discuss the new opportunities that iPSC models offer, as well as their current limitations and prospects for future development.
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