MCF-7: the first hormone-responsive breast cancer cell line.
MCF-7: the first hormone-responsive breast cancer cell line.
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发表时间：
1997-08
期刊：
影响因子：
11.2
通讯作者：
A. S. Levenson;V. Jordan;Robert H Lutie Cancer;Drs Rob Sutherland
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文献类型：
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作者：
A. S. Levenson;V. Jordan;Robert H Lutie Cancer;Drs Rob Sutherland
1997年1月2日，星期四，开发MCF-7乳腺癌细胞系的科学家HerbertSoule博士去世。当时，我们正在撰写这篇文章，以纪念Soule博士的杰出成就25周年。这些细胞来自底特律地区的一位乳腺癌患者，由底特律的密歇根癌症基金会开发，成为世界各地数百个实验室的标准模型。回想起来，这些细胞的不同用途的故事实际上是我们对乳腺癌调节细胞复制知识的发展史，它们为乳腺癌的内分泌治疗提供了独特的见解。我们的文章是作为对索尔博士的悼念和纪念而提供的。我们将追踪MCF-7细胞的研究，以阐明我们对细胞复制的看法的变化，并强调我们对雌激素信号转导途径和雌激素作用的分子生物学的理解。所有这些进展都依赖于MCF-7细胞的独特性质。此外，重要的是要认识到，细胞系统现在已经在实验治疗中找到了应用，并且这些研究的结果正在转化为临床治疗患者。如果没有博士，这一切都不可能发生。索尔作为细胞生物学家的技能。
On Thursday,January2, 1997, Dr. HerbertSoule, the scientist who developed the MCF-7 breast cancer cell line, died. At the time, we were in the process of writingthis tributeto markthe 25th anniversary of Dr. Soule's remarkableaccomplishment.The cells, derived from a breast cancer patient in the Detroit area and developed at the Michigan CancerFoundation,Detroit,became a standardmodel in hundredsof laboratories around the world. In retrospect, the story of the diverse uses of these cells is really the history of our developing knowledge of hormone-regulatedcell replication, and they provided a unique insight into the endocrine therapyof breastcancer. Our article is offered as a tributeand memorial to Dr. Soule. We will trace researchwith MCF-7 cells to illustratethe change in our ideas about cell replication and to highlight the advances in our understanding of the signal transduction pathway of estrogen and the molecular biology of estrogen action. All of these advances depended on the uniquepropertiesof MCF-7 cells. Additionally,it is important to appreciate that the cell system has now found applications in experimental therapeutics, and the results from these studies are being translated to the clinic for the treatment of patients. None of this would have been possible withoutDr. Soule's skill as a cell biologist.