Moderate intensity exercise training reverses functional aerobic impairment in HIV-infected individuals
Moderate intensity exercise training reverses functional aerobic impairment in HIV-infected individuals
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DOI：
10.1080/09540120701796900
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发表时间：
2008-10-01
影响因子：
1.7
通讯作者：
Burgess, Stephanie E.
中科院分区：
文献类型：
--
作者：
Hand, Gregory A.;Phillips, Kenneth D.;Burgess, Stephanie E.
艾滋病毒感染和艾滋病毒药物治疗给艾滋病毒携带者带来了身体和心理上的挑战。这些情况导致功能性有氧能力(FAC)下降。本研究的目的是确定中等强度有氧运动和阻力运动联合干预对HIV感染者FAC的影响。40名HIV感染者被随机分为运动组(EX)和对照组(CON)，前者完成六周的中等强度运动训练，后者未接受运动干预。每周两次，EX组完成30分钟的中等强度有氧训练，然后进行中等强度的阻力训练。在干预前和干预后，每个受试者的FAC通过分级运动平板负荷试验(GXT)确定。在基线测试中，通过基于跑步机时间的最大耗氧量估计确定的平均FAC比年龄预测值低25%，这一下降水平表明存在功能性有氧损伤(FAI)。干预后，前组的疲劳时间和最大摄氧量显著增加(p<；.001)。此外，FAI在运动训练期间被消除(比年龄预测值高1%)。在GXT的4个阶段(p=.02)、2个阶段(p=.01)、4个阶段(p=.05)和6个阶段(p=.02)，EX组也经历了心率减慢。CON在干预期间无明显变化。这些数据表明，六周的中等强度有氧和阻力联合训练可以改善艾滋病毒携带者的FAC并消除FAI。结果表明，HIV感染者普遍存在的功能障碍部分是由于缺乏训练，而通过适度的运动坚持，这种训练是可逆的。
HIV infection and HIV drug therapies result in physical and psychological challenges to those living with HIV. These conditions contribute to decreased functional aerobic capacity (FAC). The aim of this study was to determine the effects of a combined moderate-intensity aerobic and resistance exercise intervention on the FAC of HIV-infected individuals. Forty HIV-infected individuals were randomized to an exercise group (EX) who completed six weeks of moderate-intensity exercise training, or to a control group (CON) that did not receive the exercise intervention. Twice weekly, the EX group completed 30 minutes of moderate-intensity aerobic training followed by moderate-intensity resistance training. Prior to, and following, the intervention the FAC for each subject was determined by graded exercise treadmill stress test (GXT). At baseline testing, the mean FAC as determined by treadmill time-based estimation of maximal oxygen consumption was 25% below age-predicted values, a level of reduction indicating the presence of functional aerobic impairment (FAI). Following the intervention, the EX had a significant increase in time to fatigue and estimated VO2 max (p < .001). Further, FAI was eliminated (1% above age predicted values) during the exercise training. The EX group also experienced decreased heart rates during Stages (p = .02), 2 (p = .01), 4 (p = .05) and 6 (p = .02) of the GXT. The CON had no significant changes during the intervention period. These data indicate that six weeks of combined moderate-intensity aerobic and resistance training can improve FAC and eliminate FAI in those with HIV. Results suggest that the functional limitations common in HIV-infected individuals are due in part to detraining that is reversible through moderate exercise adherence.