Nosocomial, methicillin-resistant Staphylococcus aureus bacteremia:: Is it any worse than nosocomial methicillin-sensitive sensitive Staphylococcus aureus bacteremia
Nosocomial, methicillin-resistant Staphylococcus aureus bacteremia:: Is it any worse than nosocomial methicillin-sensitive sensitive Staphylococcus aureus bacteremia
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DOI：
10.1086/501707
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发表时间：
2000-10-01
影响因子：
4.5
通讯作者：
Johnson, B
中科院分区：
文献类型：
--
作者：
Selvey, LA;Whitby, M;Johnson, B
目的：通过考虑医疗环境中感染甲氧西林耐药金黄色葡萄球菌（MRSA）和甲氧西林敏感金黄色葡萄球菌（MSSA）的患者的易感因素和结局，确定这两种细菌的比较毒力。设计：分析504例菌血症患者的历史队列（316例MSSA和188例MRSA），检查与死亡率相关的因素。MRSA发展的风险因素包括男性、因创伤入院、免疫抑制、存在中央血管线或留置导尿管以及MRSA感染的既往史。总死亡率为22%。在MRSA组中，菌血症导致的死亡率显著较高（危险比，1.68; P
OBJECTIVE: To determine the comparative virulence of methicillin-resistant Staphylococcus aureus (MRSA) and methicllin-sensitive S aureus (MSSA) by consideration of predisposing factors and outcomes in patients infected with these organisms in the healthcare setting.DESIGN: Analysis of an historical cohort of 504 bacteremic patients (316 MSSA and 188 MRSA), examining factors associated with mortality.SETTING: A 916-bed, university-affiliated, tertiary referral hospital.RESULTS: Risk factors for the development of MRSA include male gender, admission due to trauma, immunosuppression, presence of a central vascular line or an indwelling urinary catheter, and a past history of MRSA infection. Overall mortality was 22%. Death due to bacteremia was significantly greater in the MRSA group (risk ratio, 1.68; P