Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation.
Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation.
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DOI：
10.1016/j.tem.2009.11.004
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Brent GA
中科院分区：
文献类型：
--
作者：
Liu YY;Brent GA
Thyroid hormone influences diverse metabolic pathways important in lipid and glucose metabolism, lipolysis, and regulation of body weight. Recently, it has been recognized that thyroid hormone receptor (TR) interacts with transcription factors that predominantly respond to nutrient signals including the peroxisome proliferator-activated receptors (PPARs), liver X receptor (LXR), and others. Crosstalk between thyroid hormone signaling and these nutrient responsive factors occurs through a variety of mechanisms: competition for retinoid X receptor (RXR) heterodimer partners, DNA binding sites, and transcriptional co-factors. This review focuses on the mechanisms of interaction of thyroid hormone signaling with other metabolic pathways, and the importance of understanding these interactions to develop therapeutic agents for treatment of metabolic disorders, such as dyslipidemias, obesity, and diabetes.
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