Simultaneous gradient-echo/spin-echo EPI of graded ischemia in human skeletal muscle
Simultaneous gradient-echo/spin-echo EPI of graded ischemia in human skeletal muscle
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DOI：
10.1002/jmri.1880080516
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发表时间：
1998-09-01
期刊：
影响因子：
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通讯作者：
Kissebah, AH
中科院分区：
文献类型：
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作者：
Donahue, KM;Van Kylen, J;Kissebah, AH
本研究的目的是评估血液氧合水平依赖(BOLD)方法在提供有关骨骼肌血流的时间和空间信息方面的有用性。使用同步梯度回波(GE)和自旋回波(SE)成像序列(GE/SE)和交替TE序列，在阶梯式反应性充血范例中采集小腿骨骼肌的图像。在缺血和反应性充血期间测量的GE和SE松弛速率(Delta R2*，Delta R2)的变化随袖带扩张持续时间(缺血期)而变化，在袖带扩张持续超过120秒时，比目鱼肌的变化大于腓肠肌。与缺血相比，反应性充血期的Delta R2*/Delta R2比值较小。考虑到在反应性充血时比在缺血时有更大比例的毛细血管灌流，这一发现表明磁化率方法，其依赖于室大小，可能提供一种测量骨骼肌中大小血管相对分布的方法。
The goal of this study was to evaluate the usefulness of blood oxygenation level-dependent (BOLD) methodologies to provide temporal and spatial information about skeletal muscle perfusion. A simultaneous gradient echo (GE) and spin-echo (SE) imaging sequence (GE/SE) with alternating TE was used to acquire images of leg skeletal muscle throughout a stepped reactive hyperemia paradigm. The change in both the GE and SE relaxation rates (Delta R2*, Delta R2) measured during ischemia and reactive hyperemia scaled with the duration of cuff inflation (the ischemic period) plateaued for cuff inflations lasting longer than 120 seconds and were greater in soleus muscle than in gastrocnemius. The ratio Delta R2*/Delta R2 was found to be less during the reactive hyperemia period relative to ischemia. Considering that a greater proportion of capillary vessels are perfused during reactive hyperemia than during ischemia, this finding suggests that magnetic susceptibility methodologies, with their dependence on compartment size, may provide a measure of the relative distribution of small and large vessels in skeletal muscle.