Infant feeding method and obesity: body mass index and dual-energy X-ray absorptiometry measurements at 9-10 y of age from the Avon Longitudinal Study of Parents and Children (ALSPAC)
Infant feeding method and obesity: body mass index and dual-energy X-ray absorptiometry measurements at 9-10 y of age from the Avon Longitudinal Study of Parents and Children (ALSPAC)
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DOI：
10.1093/ajcn/85.6.1578
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发表时间：
2007-06-01
影响因子：
7.1
通讯作者：
Ness, Andrew R.
中科院分区：
文献类型：
--
作者：
Toschke, Andre M.;Martin, Richard M.;Ness, Andrew R.
背景：之前的研究报告称母乳喂养与体重指数（BMI；单位为 kg /m(2)）之间的关联不一致。与身体脂肪的关联尚不清楚。目的：我们调查了母乳喂养与双能 X 射线吸收测定法测量的脂肪之间的关系。设计：前瞻性队列研究涉及 4325 名 9-10 岁单身人士，以评估 BMI 以及总脂肪量和躯干脂肪量的主要结果。结果：母乳喂养的患病率为 82%。在粗略分析中，母乳喂养与母乳喂养持续时间（-4.4%；95% CI：- 3.1%，- 5.6%）和躯干脂肪量（-0.5%；95% CI：-1.1%，0.1%）的总脂肪量[每个类别增加的变化百分比（4个类别）]呈负相关；肥胖的几率通过总[比值比（OR）：0.81； 95% CI: 0.75,0.88] 和躯干 (OR: 0.78; 95% CI: 0.71, 0.84) 脂肪量位于前十分之一。在调整后的模型中，母乳喂养与平均总脂肪量的负相关减弱了 59%（母乳喂养持续时间每个类别增加的变化百分比：-1.8%；95% CI：-0.5%，-3.1%），但与躯干脂肪量的相关性（母乳喂养持续时间每个类别增加的变化百分比：-0.6%；95% CI：0.0%，-1.3%）和总脂肪量的 OR前十分之一的脂肪量（0.76；95% CI：0.69，0.84）和躯干脂肪量（0.74；95% CI：0.67，0.81）几乎没有变化。母乳喂养 >= 6 个月的儿童总脂肪量处于前十分位数的几率最低（OR：0.45；95% CI：0.33，0.62）。在多变量模型中，几乎没有证据表明母乳喂养与 BMI 平均值或阈值相关。结论：母乳喂养与平均总脂肪量的保护性关联在调整混杂因素后有所减弱，这表明混杂因素可以解释这种关联。如果母乳喂养持续 >= 6 个月，可以预防肥胖。
Background: Previous studies reported inconsistent associations between breastfeeding and body mass index (BMI; in kg /m(2)). Associations with body fatness are unknown.Objective: We investigated the association of breastfeeding with fatness measured by dual-energy X-ray absorptiometry.Design: The prospective cohort study involved 4325 singletons with measurements at 9-10 y of age to assess the main outcomes of BMI and total and trunk fat masses.Results: Prevalence of any breastfeeding was 82%. In crude analyses, breastfeeding was inversely associated with total fat mass [% change per category increase (4 categories)] in breastfeeding duration (-4.4%; 95% CI: - 3.1%, - 5.6%) and trunk fat mass (-0.5%; 95% CI: -1.1%, 0.1%); the odds of adiposity were measured by total [odds ratio (OR): 0.81; 95% CI: 0.75,0.88] and trunk (OR: 0.78; 95% CI: 0.71, 0.84) fat masses in the top decile. In adjusted models, the inverse association of breastfeeding with mean total fat mass was attenuated by 59% (% change per category increase in breastfeeding duration: -1.8%; 95% CI: -0.5%, -3.1%), but associations with trunk fat mass (% change per category increase in breastfeeding duration: -0.6%; 95% CI: 0.0%, -1.3%) and the ORs for total (0.76; 95% CI: 0.69, 0.84) and trunk (0.74; 95% CI: 0.67, 0.81) fat masses in the top decile were little altered. Children breastfed >= 6 mo had the lowest odds of total fat mass in the top decile (OR: 0.45; 95% CI: 0.33, 0.62). In multivariate models, there was little evidence that breastfeeding was associated with mean or threshold values of BMI.Conclusions: The protective association of breastfeeding with mean total fat mass was attenuated somewhat after adjustment for confounders, which indicated that confounding may explain this association. Breastfeeding may protect against obesity if maintained for >= 6 mo.