Evaluation of Blood — Brain Barrier Permeability Changes in Rhesus Monkeys and Man Using 82Rb and Positron Emission Tomography
Evaluation of Blood — Brain Barrier Permeability Changes in Rhesus Monkeys and Man Using 82Rb and Positron Emission Tomography
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使用 82Rb 和正电子发射断层扫描评估恒河猴和人的血液-脑屏障通透性变化
DOI：
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发表时间：
1981
影响因子：
1.3
通讯作者：
T. Budinger
中科院分区：
文献类型：
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作者：
C. Yen;T. Budinger
从便携式发生器[82 Sr（25天）-82 Rb（76秒）]获得的82 Rb脑动态位置断层扫描提供了在生理和临床研究中研究血脑屏障（BBB）渗透性的手段。恒河猴颈动脉内灌注3 M尿素，单侧开放血脑屏障.这种渗透屏障的打开允许静脉注射的氯化铷进入大脑。使用82 Rb和正电子发射断层扫描非侵入性地证明了BBB开口，并通过组织样本中86 Rb的积累来证实。正电子发射断层扫描研究可以每5分钟重复一次，表明动态断层扫描或静态成像可用于研究由各种伤害性刺激引起的BBB通透性变化。人类受试者中的脑肿瘤很容易被检测到，因为肿瘤中和肿瘤周围通常存在BBB通透性破坏。
Dynamic position tomography of the brain with 82Rb, obtained from a portable generator [82Sr (25 days) – 82Rb (76 sec)], provides a means of studying blood-brain barrier (BBB) permeability in physiological and clinical investigations. The BBB in rhesus monkeys was opened unilaterally by intracarotid infusion of 3 M urea. This osmotic barrier opening allowed entry into the brain of intravenously administered rubidium chloride. The BBB opening was demonstrated noninvasively using 82Rb and positron emission tomography and corroborated by the accumulation of 86Rb in tissue samples. Positron emission tomography studies can be repeated every 5 min and indicate that dynamic tomography or static imaging can be used to study BBB permeability changes induced by a wide variety of noxious stimuli. Brain tumors in human subjects are readily detected because of the usual BBB permeability disruption in and around the tumors.