IFN-gamma production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB.
IFN-gamma production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB.
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DOI：
10.1086/596742
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发表时间：
2009-03-01
期刊：
影响因子：
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通讯作者：
García VE
中科院分区：
文献类型：
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作者：
Pasquinelli V;Townsend JC;Jurado JO;Alvarez IB;Quiroga MF;Barnes PF;Samten B;García VE
干扰素-γ (IFN-γ) 对于预防结核分枝杆菌至关重要，转录因子 cAMP 反应元件结合蛋白 (CREB) 会增加 IFN-γ 转录。我们确定了跨膜受体信号淋巴细胞激活分子 (SLAM) 和白细胞介素 17 (IL-17) 是否影响结核病患者的 CREB 磷酸化和 IFN-γ 产生。当来自结核病患者的 T 细胞被结核分枝杆菌激活时，80% 的 SLAM+ T 细胞表达磷酸化的 CREB，SLAM 激活增加了 CREB 磷酸化和 IFN-γ 的产生。相反，IL-17 下调 SLAM 表达、CREB 磷酸化和 IFN-γ 产生。因此，IL-17 和 SLAM 对结核病患者通过 CREB 激活产生 IFN-γ 具有相反的作用。
Interferon-γ (IFN–γ) is crucial for protection against Mycobacterium tuberculosis, and the transcription factor cAMP response element binding protein (CREB) increases IFN-γ transcription. We determined whether the transmembrane receptor signaling lymphocyte activation molecule (SLAM) and interleukin-17 (IL-17) affect CREB phosphorylation and IFN-γ production in persons with tuberculosis. When T cells from patients with tuberculosis were activated with M. tuberculosis, 80% of SLAM+ T cells expressed phosphorylated CREB, and SLAM activation increased CREB phosphorylation and IFN-γ production. In contrast, IL-17 down-regulated SLAM expression, CREB phosphorylation, and IFN-γ production. Therefore, IL-17 and SLAM have opposing effects on IFN-γ production through CREB activation in persons with tuberculosis.