Effects of Anticholinergic Drugs on Cognitive Function in Older Australians: Results from the AIBL Study
Effects of Anticholinergic Drugs on Cognitive Function in Older Australians: Results from the AIBL Study
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DOI：
10.1159/000325171
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发表时间：
2011-01-01
影响因子：
2.4
通讯作者：
Ellis, Kathryn A.
中科院分区：
文献类型：
--
作者：
Sittironnarit, Gobhathai;Ames, David;Ellis, Kathryn A.
背景/目标：抗胆碱能药物处方对老年痴呆患者和非痴呆患者认知功能的不良影响的性质和程度尚不清楚。研究方法：我们计算了澳大利亚成像、生物标志物和生活方式（Aibl）老龄化研究参与者服用的药物的抗胆碱能负荷（ACL），该研究包括211名阿尔茨海默病（AD）患者、133名轻度认知障碍（MCI）患者和768名健康对照（HC），年龄均超过60岁。检查每个诊断组（HC、MCI、AD）ACL与认知功能之间的关联。结果：HC组内的高ACL与Stroop颜色和不一致试验的反应速度显著较慢相关。ACL和认知之间没有其他显着的关系。结论：在这个大的队列中，处方的抗胆碱能药物似乎对精神速度和执行功能有适度的影响，但对健康老年人的其他认知领域没有影响。版权所有（C）2011 S. Karger AG，巴塞尔
Background/Aims: The nature and extent of adverse cognitive effects due to the prescription of anticholinergic drugs in older people with and without dementia is unclear. Methods: We calculated the anticholinergic load (ACL) of medications taken by participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing, a cohort of 211 Alzheimer's disease (AD) patients, 133 mild cognitive impairment (MCI) patients and 768 healthy controls (HC) all aged over 60 years. The association between ACL and cognitive function was examined for each diagnostic group (HC, MCI, AD). Results: A high ACL within the HC group was associated with significantly slower response speeds for the Stroop color and incongruent trials. No other significant relationships between ACL and cognition were noted. Conclusion: In this large cohort, prescribed anticholinergic drugs appeared to have modest effects upon psychomotor speed and executive function, but not on other areas of cognition in healthy older adults. Copyright (C) 2011 S. Karger AG, Basel